目 的 作業現場での水銀への暴露 による神経系 の障害 は,産 業衛生上の問題 として取 り上げ られている1).水 銀 によ る神経系の障害発現 には神経細胞の脱落が関与 している ことが知 られている. PC12細 胞はラッ トの副腎よ り得 られた褐色細胞腫由 来の株化細胞で,神 経成長菌子(NGF)に 反応 して神 経突起の成長やカテコールア ミンの合成促進等の神経細 胞様分化を起こす ことが知 られ,神 経細胞 の分化機構の 研究等に多 く用 いられている細胞株 であ る2). 本研究 では, NGFに よって神経細 胞様 に分化 した PC12細 胞 を塩化第二水銀を添加 した培地中で培養 した ときに起 こる細胞死が, RNA合 成阻害剤,蛋 白合成阻 害剤もしくはエ ンドヌクレアーゼ阻害剤の添加で抑制で きるか否かを明 らかにする事 によ り,水 銀暴露 に よる P...

In embryological work using vital dyes it is highly desirable to be able to study the distribution of the dyes in fixed material, whether examined in toto or after embedding in paraffin and serial sectioning. However, both fixation and dehydration present problems for the preservation of colour in vitally stained cells. Some fixatives preserve some dyes but, so far as I am aware, none will pres...

The current study was aimed at isolating and identifying the halophilic and halotolerant bacteria which can produce mercuric reductase in Gavkhuni wetland in Iran. Moreover, tracking and sequencing merA gene and kinetic properties of mercuric reductase in the selected strain were performed in this study. Soil samples were taken from Gavkhuni wetland and cultured in nutrient agar medium...

A 29-year-old gardener developed acute renal failure following the ingestion of 'Mersil', a combination of mercurous and mercuric chloride, achieving a plasma mercury concentration of 22,000 nmol/litre (400 micrograms/litre). Haemodialysis and charcoal haemoperfusion were ineffective in removing mercury despite prior treatment with the chelating agent dimercaprol. The acute renal failure resolv...

Plasma Enzyme Activities in Coturnix Quail Fed Graded Doses of DDE, Polychlorinated Biphenyl, Malathion and Mercuric Chloride. DIETER, M. P. (1974). Toxicol. Appl. Pharmacol. 27, 86-98. Male Coturnix quail (Coturnix coturnixjaponica) were fed diets for 12 weeks containing graded levels of DDE, polychlorinated biphenyl (Aroclor 1254), malathion, and mercuric chloride. Birds were bled prior to ex...