The microsatellite instability (MSI) phenotype may constitute an important biomarker for patient response to immunotherapy, particularly to anti-programmed death-1 inhibitors. MSI is a type of genomic instability caused by a defect in DNA mismatch repair (MMR) proteins, which is present mainly in colorectal cancer and its hereditary form, hereditary nonpolyposis colorectal cancer. Gastrointesti...

Background Cardiac magnetic resonance imaging (CMR) can be used to determine both myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). MI size as assessed by hyperenhancement on late gadolinium enhancement (LGE) has been shown to decrease approximately 25% during the first week after infarction. The aim of this study was to determine ...

Sustainability of rice production under flooding conditions has been challenged by water shortage and food demand. Applying higher nitrogen fertilization could be a practical solution to alleviate the deleterious effects stress on lowland (Oryza sativa L.) in semi-arid conditions. For this purpose, field experiments were conducted during summer 2017 2018 seasons. These trials as split-split bas...

OBJECTIVE In acute myocardial infarction, cardiovascular magnetic resonance (CMR) allows for quantifying the extent of salvaged myocardium after reperfusion as a potential strong end point for clinical trials. The aim of this study was to investigate whether the early prognostic significance of myocardial salvage assessed by CMR is sustained at long-term clinical follow-up in patients with ST-e...

Abstract Background Maintaining hemodynamic stability requires constant complex interaction between multiple vascular and extravascular factors. There are varieties of parameters that determine the same few them used to predict instability at earliest. Shock Index (SI), Modified (MSI) Index-Pediatric age-Adjusted (SIPA) have been studied constantly in different clinical settings. They best non-...

background: this study was designed to determine the frequency of microsatellite instability (msi) in young iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. methods : microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. clinicopathologic characte...

Given the importance of forest ecosystems, the availability of reliable, spatially explicit information about the site-specific climate sensitivity of tree species is essential for implementing suitable adaptation strategies. In this study, airborne hyperspectral data were used to assess the response of deciduous species (dominated by European beech and Sessile and Pedunculate oak) to water str...

Microsatellite instability (MSI) is a well-recognized phenomenon that is classically a feature of tumors in the hereditary non-polyposis colorectal syndrome. Ten to 15% of sporadic colorectal cancers, however, will have MSI. Microsatellite unstable tumors can be divided into two distinct MSI phenotypes: MSI-high (MSI-H) and MSI-low (MSI-L). MSI sporadic colorectal cancers with a high level of M...

study area is located in west of iran with relatively rough topography. lithologic units in the region belong from jurassic and cretaccous till recent era. the study area of the alvand mountain region is related to the tectonic zone of the sanandaj-sirjan region and the area dominant neo-tectonic regime appears to be compressional-extensional type. one of the identification tools to find out th...

abstract the effect of land use type on soil functioning within an ecosystem can be assessed and monitored using soil quality attributes. such studies, which are carried out to create a balance between the biological production and the maintenance and improvement of land resource quality, provide a framework for land degradation control and also for identification of sustainable management. in ...