OBJECTIVES Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells expose...

Previous studies by us have strongly indicated a role for the N-methyl-D-aspartate (NMDA) receptor in the pathogenesis of experimental allergic encephalomyelitis (EAE) and, moreover, the loss of blood-brain barrier (BBB) integrity implicit in the disease. The current investigation has used the NMDA receptor antagonist memantine to modify the neurological course of EAE and, in particular, preven...

Glutamate is the major excitatory neurotransmitter in the brain. The NMDA subtype of glutamate receptors (NMDAR) is known to mediate many physiological neural functions. However, excessive activation of NMDARs contributes to neuronal damage in various acute and chronic neurological disorders. To avoid unwanted adverse side effects, blockade of excessive NMDAR activity must therefore be achieved...

Chronic treatment of adult male F-344 rats (9-12 months old) with therapeutically relevant doses of memantine (30 mg/kg/day in chow for > 8 weeks) increased the maintenance of long-term potentiation of field excitatory postsynaptic potentials from perforant path-granule cell hippocampal synapses recorded in the fascia dentata in vivo. In contrast, there was no effect of memantine on baseline sy...

INTRODUCTION/AIM In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. METHODS Male Albi...

PURPOSE To test whether memantine can prevent methotrexate-induced cognitive deficits in a preclinical model. EXPERIMENTAL DESIGN After noting that methotrexate exposure induces prolonged elevations of the glutamate analog homocysteic acid (HCA) within cerebrospinal fluid, we tested whether intrathecal injection of HCA would produce memory deficits similar to those observed after intrathecal ...

1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2. Minocycline but not memantine or glycoconjugate protected cultured cells and warrants further investigation.

Context: Increased survival of patients with cancer raises the need to pay attention long-term side effects. Patients brain metastasis experienced cognition failure after whole-brain radiotherapy. This review aimed at concluding efficacy Memantine in preserving cognitive function by reducing toxicity radiotherapy for metastatic cancers. Evidence Acquisition: Published studies evaluating memanti...

OBJECTIVE: To determine the clinical efficacy and safety of memantine in Huntington’s disease (HD). BACKGROUND: The excitatory activity of Lglutamate may affect the progression of HD. Memantine, an N-methyl-Daspartate antagonist used to treat Alzheimer’s dementia, could theoretically retard the progression of this disorder, improve cognition, and improve chorea. METHODS: HD patients were recrui...

To the Editor: Memantine is an N-methyl-D-aspartate (NMDA) receptor agonist. It was recently approved in Europe and the United States for treating dementia and has been shown to reduce clinical deterioration in moderate-to-severe Alzheimer’s disease and in vascular dementia.1 Although memantine has been reported to be useful for psychotic symptoms (delusions and hallucinations) in patients with...