OBJECTIVE Bertolotti's syndrome is a spine disorder characterized by the occurrence of a congenital lumbar transverse mega-apophysis in a transitional vertebral body that usually articulates with the sacrum or the iliac bone. It has been considered a possible cause of low back pain. METHOD We analyzed the cases of Bertolotti's syndrome that failed clinical treatment and reviewed the literatur...

A practical data recovery method is proposed for the strain data lost during the safety monitoring of mega columns. The analytical relations among the measured strains are derived to recover the data lost due to unexpected errors in long-term measurement during construction. The proposed technique is applied to recovery of axial strain data of a mega column in an irregular building structure du...

We discuss the results of the MEGA microlensing campaign towards M31. Our analysis is based on an analytical evaluation of the microlensing rate, taking into account the observational efficiency as given by the MEGA collaboration. In particular, we study the spatial and time duration distributions of the microlensing events for several mass distribution models of the M31 bulge. We find that onl...

We announce the release of an advanced version of the Molecular Evolutionary Genetics Analysis (MEGA) software, which currently contains facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis. In version 6.0, MEGA now enables the inference of timetrees, as it implements the RelTime method for estimating divergence times for ...

Computational diagnosis of amino acid variants in the human exome is the first step in assessing the disruptive impacts of non-synonymous single nucleotide variants (nsSNVs) on human health and disease. The Molecular Evolutionary Genetics Analysis software with mutational diagnosis (MEGA-MD) is a suite of tools developed to forecast the deleteriousness of nsSNVs using multiple methods and to ex...

Many attempts have been made in the past to discover an ideal treatment for typhoid fever. The first promising attempt in this direction was made by McSweeney in 1946 who published reports of 5 cases of typhoid fever treated with large doses of penicillin and sulphathiazole (McSweeney, 1946). Earlier in the same year Bigger (1946) had observed that the growth of Salmonella typhi in cultures was...

Upon induction, Bacillus megaterium 216 produces the bacteriocin megacin A-216, which leads to lysis of the producer cell and kills B. megaterium and a few other bacterial species. The DNA region responsible for megacinogeny was cloned in B. megaterium. The nucleotide sequence of a 5,494-bp-long subfragment was determined, and the function of the genes on this fragment was studied by generating...

Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels. We have engineered a polymeric nanoparticle encapsulated formulation of curcumin (NanoCurc) to har...

This paper focuses on the contribution of mega events onto the development of a green economy at the event host location and discusses how to measure it. The promises of organizers usually are very ambitious but the question remains as to how realistic these claims are. This question will be addressed in three sections by using methods that are primarily analytical and critical rather than an e...

This thesis uses the 2010 FIFA World Cup in South Africa, which was framed as a catalyst for economic growth and broader development, to consider the relationship between global sporting events and pro-poor priorities. The study is driven by three main questions. To what extent did the World Cup deliver on its expectations; are event-driven strategies compatible with pro-poor needs; and why, gi...