Midazolam clearance is used to phenotype hepatic CYP3A activity but requires multiple plasma samples following a single intravenous dose. The authors evaluated the use of a limited sampling scheme, using different assay techniques to determine the reproducibility of such a strategy in estimating midazolam AUC. Seventy-three healthy adults received midazolam as a single intravenous bolus dose. A...

The accurate estimation of reference evapotranspiration (ETref) is a crucial component for modeling hydrological and ecological cycles. goal this study was the calibration 32 empirical equations used to determine ETref in three classes temperature-based, solar radiation–based, mass transfer–based evapotranspiration. based on measurements taken between years 1990 2019 at 41 synoptic stations loc...

ABSTRACT-Determining hydraulic conductivity of soil is difficult, expensive, and time-consuming. In this study, Algorithm Genetic and geostatistical analysis and Neural Networks method are used to estimate soil saturated hydraulic conductivity using the properties of particle size distribution. The data were gathered from 134soil profiles from soil and lander form studies of the Ardabil Agricul...

Time series of quarterly observations on Gross Domestic Product (GDP) is collected and used in this study. Forecasting results of ANNs are compared with those of the Autoregressive Integrated Moving Average (ARIMA) and regression as benchmark methods. Using Root Mean Square Error (RMSE), the empirical results show that ANN performs better than the traditional methods in forecasting GDP.

Most weather monitoring systems used for measuring meteorological parameters are imported. For many developing countries like Nigeria, importing instruments is practically bedeviled with problems due to erratic exchange rates. This has hampered weather-related research especially in radio propagation studies where finite data required. In the quest develop a home-grown system, this paper presen...

This paper presented the levels of PM2.5 and PM10 in different stations at the city of Sabzevar, Iran. Furthermore, this study was an attempt to evaluate spatial interpolation methods for determining the PM2.5 and PM10 concentrations in the city of Sabzevar. Particulate matters were measured by Haz-Dust EPAM at 48 stations. Then, four interpolating models, including Radial Basis Functions (RBF)...

Problem statement: The fundamental frequency (F0) of the human speech corresponds to the vibration frequency of the human vocal chords. To extract the F0 from a speech utterance, one approach is based on the Cepstral analysis. In Thai, there are four main dialects spoken by Thai people residing in four core region including central, north, northeast and south regions. Environmental noises are a...

In this paper, we present the simulation of the propagation characteristics of the picocellular propagation channel environment. The first aim has been to find a correct description of the environment for received wave. The result of the first investigations is that the environment of the indoor wave significantly changes as we change the electric parameters of material constructions. A modifie...