Reduced antiplatelet effect of clopidogrel assessed with multiple electrode aggregometry (MEA) and vasodilator stimulated phosphoprotein-phosphorylation (VASP-P) assay has been proven to predict major adverse cardiovascular events (MACE) after coronary stenting. So far no consecutive registry has evaluated the usefulness of different adenosine diphosphate-based platelet function tests to predic...

Copulas are a general tool for assessing the dependence structure of random variables. Important properties as well as a number of examples are discussed, including Archimedean copulas and the Marshall-Olkin copula. As measures of the dependence we consider linear correlation, rank correlation, the coefficients of tail dependence and association. Copulas are a tool for modeling and capturing th...

BACKGROUND Microelectrode array (MEA) devices are frequently used in neural circuit studies, especially in retinal prosthesis. For a high throughput stimulation and recording paradigm, it is desirable to obtain the responses of multiple surface RGCs initiated from the electrical signals delivered to multiple photoreceptor cells. This can be achieved by an high density MEA-tissue-MEA (MTM) sandw...

H(+)-pumping ATPases were detected in microsomal vesicles of oat (Avena sativa L. var Lang) roots using [(14)C]methylamine distribution or quinacrine fluorescent quenching. Methylamine (MeA) accumulation into vesicles and quinacrine quench were specifically dependent on Mg,ATP. Both activities reflected formation of a proton gradient (DeltapH) (acid inside) as carbonyl cyanide m-chlorophenylhyd...

This work provides new viscosity data of unloaded and partially carbonated aqueous monoethanolamine-piperazine (MEA-PZ) solutions at temperatures between 303.15 373.15 K a N2 pressure 400 kPa. In both cases, the MEA-PZ was measured three different concentrations PZ 5, 10, 15 wt % by keeping concentration MEA constant 30 %. For solutions, measurements were performed varying CO2 0.13 0.55 mol CO2...

their excellent safety profile, despite their low transgene expression efficiency in comparison to that of viral vectors. For their administration, cationic lipid-mediated transfer is a promising approach, because of its low toxicity, ease of preparation, and potential for active targeting. One disadvantage associated with the use of DNA–cationic lipid complexes systemically is the induction of...

So far, we primarily used voltage-controlled stimuli of varying strength and duration. Experiments with current-controlled pulses are underway. It is worth noting that while modellers prefer current-controlled pulses because they are easier to interpret biophysically, some of the best results in the field have been achieved using voltage-controlled stimuli. Real-world stimulus waveforms are nev...

BACKGROUND The standard method of assessment of platelet function is represented by light transmission aggregometry (LTA), performed in citrated platelet-rich plasma (PRP). With LTA, decrease and subsequent post-cardiopulmonary bypass (CPB) recovery of platelet function have been reported during cardiac surgery. Multiple electrode aggregometry (MEA) may be used as point-of-care method to monito...