BACKGROUND AND PURPOSE The middle cerebral artery (MCA) "dot" sign consists of hyperdensity of an arterial structure, seen as a dot in the sylvian fissure. The MCA dot sign has been proposed to indicate thrombosis of M2 or M3 MCA branches, analogous to the hyperdense middle cerebral artery (HMCA) sign indicating M1 thrombosis. The MCA dot sign has not been validated previously against the gold ...

BACKGROUND Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute ischemic stroke. Using intravital microscopy, we investigated and characterized the sequence of downstream microvascular thromboinflammation in an ischemia/reperfusion acute ischemic stroke model. METHODS AND RESULTS Rats underwent transient monofilament...

BACKGROUND AND PURPOSE Microanatomy studies reveal that most penetrating branches of middle cerebral artery (MCA) arise from the dorsal-superior surface of the trunk. Using high-resolution MRI, we sought to explore the plaque distribution of MCA atherosclerosis and its clinical relevance in relation to the orifices of penetrating arteries. METHODS We retrospectively analyzed the imaging and c...

We have generated and characterized a monoclonal antibody (McA Tg-HYL) that recognizes sea urchin hyalin as evidenced by immunofluorescence staining of the hyaline layer (HL) and immunoblot staining of the hyalin protein band. On immunoblots of HL extracts only the hyalin protein reacted with McA Tg-HYL. Immunoprecipitates of radioactive proteins from embryos incubated with [35S]methionine yiel...

We have developed a photochemical model of thrombotic middle cerebral artery (MCA) occlusion in the guinea pig for investigating factors contributing to the development of cerebral infarction. In this model, cyclic flow reductions (CFRs) after recanalization of the MCA are a common observation and might contribute to the development of cerebral infarction. Therefore, we sought to measure the ti...

BACKGROUND Acute tandem cervical dissecting internal carotid artery (ICA) occlusion and intracranial embolic middle cerebral artery (MCA) occlusion can be devastating, and the optimal treatment strategy for this condition has not been established yet. CASE DESCRIPTION A 45-year-old male presented with aphasia and right hemiparesis preceded by neck pain. Computed tomography showed a high-densi...

Maurocalcine (MCa), a 33 amino acid toxin obtained from scorpion venom, has been shown to interact with the isolated skeletal-type ryanodine receptor (RyR1) and to strongly modify its calcium channel gating. In this study, we explored the effects of MCa on RyR1 in situ to establish whether the functional interaction of RyR1 with the voltage-sensing dihydropyridine receptor (DHPR) would modify t...

Aphasia is an acquired language impairment caused by damage in the regions of brain that support language. The Main Concept Analysis (MCA; Kong, 2016b) a published formal assessment battery allows quantification presence, accuracy, completeness, and efficiency content spoken discourse produced persons with aphasia (PWA). It utilizes sequential picture description task (with four sets pictures) ...

Background: The use of middle cerebral artery (MCA) angioplasty compared with drug therapy has been controversial. Few studies have reported the correlations between cognitive function improvement and MCA angioplasty. This study aimed to explore neurocognitive after in patients stenosis (MCAS) objective ischemia.

Meerkat Clan Algorithm (MCA) is a nature-based metaheuristic algorithm which imitates the intelligent behavior of meerkat animal. This paper presents an improvement on MCA based chaotic map and crossover strategy (MCA-CC). These two strategies increase diversification intensification proposed boost searching ability to find more quality solutions. The 0-1 knapsack problem was solved by basic im...