respectively, relative to the S. maltophilia strain IAM 1566 protein) (Figure 1). S. maltophilia is a Gram-negative bacterium found in a variety of environments, including soil, water and plants, and is therefore a potential reservoir of the MBL gene. Similar to POM-1 and L1 MBLs, the ability of the PAM-1 enzyme to hydrolyse carbapenems might be relatively low; consequently, the PAM-1-positive ...

23 We describe the occurrence of blaVIM-2 in 10 carbapenem-resistant Pseudomonas monteilii 24 strains isolated from different clinical samples in our hospital in Northern Spain. All the 25 blaVIM-2-harbouring P. monteilii isolates possessed a class 1 integron, with the cassette array 26 [intI1_blaVIM-2_aac(6’)-Ib_qacE1_sul1]. Our results show the emergence of VIM-227 producing multidrug-resist...

conclusions beside our study, the detection of mbl genes were reported in a few studies conducted in iran. the spread of detected mbls producing p. aeruginosa were unprecedented in the region due to the lack of independent related researches or the novel incidence of these genes. this detection must be noted by associated clinical and health care services. results from 240 p. aeruginosa isolate...

Purpose: To investigate the frequency of MBLs in Pseudomonas and Acinetobacter species with E-test, to determine risk factors evaluate demographic clinical features infected patients. Materials methods: Imipenem or meropenem resistance isolated from several samples conventional methods were evaluated imipenem EDTA E-test presence Metallo-β-lactameses MBL was examined. Several isolates screened ...

Abstract. Ship tracks in subtropical marine low clouds are simulated and investigated using large-eddy simulations. Five variants of a shallow stratocumulus-topped boundary layer (MBL) chosen to span range background aerosol concentrations variations free-tropospheric moisture. Idealized time-invariant meteorological forcings approximately steady-state constitute the conditions. We investigate ...

Class B β-lactamases are known as metallo-β-lactamases (MBLs) and they hydrolyze most β-lactams, including carbapenems. IMP-18, an MBL cloned from Pseudomonas aeruginosa, was overexpressed, purified and crystallized by vapour diffusion for X-ray crystallographic analysis. Preliminary X-ray analysis showed that the crystal diffracted to 2.4 Å resolution and belonged to the tetragonal space group...

A total of 87 Acinetobacter baumannii nonrepetitive consecutive clinical isolates were tested for the presence of metallo-beta-lactamases (MBLs). Results of phenotypic assays (MBL Etest, imipenem/imipenem-EDTA combined-disk test, and imipenem/EDTA double-disk synergy test) were negative in all cases, but molecular testing revealed the presence of two bla(VIM-1)-carrying isolates. One isolate ha...

Acquired resistance is through the production of AmpC Beta Lactamases (AmpC), Extended Spectrum Beta Lactamases (ESBL) and Metallo Beta-Lactamases Enzymes (MBL). Resistance to β-lactam antibiotics is associated with production of ESBL which can hydrolyze oxyimino β-lactams such as cefotaxime, ceftriaxone, ceftazidime and monobactams, however, without any effect on cephamycins, carbapenems and r...