Background—Patients with cystic fibrosis (CF) have significantly decreased plasma concentrations of nutrient antioxidant vitamins, especially of â-carotene, which is thought to result from fat malabsorption and chronic pulmonary inflammation. The aim of this double blind, placebo controlled study was to investigate the eVect of oral â-carotene supplementation for six months on clinical paramete...

The 0-24-h urinary metabolic profile of cyclophosphamide was inves tigated in a series of 14 patients with various malignancies receiving combination chemotherapy including i.v. cyclophosphamide. This was accomplished using combined thin-layer chromatography-photographydensitometry, which can quantitate cyclophosphamide and its four prin cipal urinary metabolites (4-ketocyclophosphamide, nor-ni...

Several human monoclonal antibodies directed to tumor-associated glycolipid antigens have been established, but more than one-half of them react with gangliosides and the others react with neutral glycolipids. We report here the first establishment of a human IgM monoclonal antibody directed to the sulfated glycolipid. This monoclonal antibody, M14-376, did not react with SM<and Sm„ which hav...

In protection experiments (5-formyltetrahydrofolate or 5-methyltetrahydrofolate added to cultures in vitro at the same time as methotrexate), 5-methyltetrahydrofolate af forded the same degree of protection as did formyltetrahydrofolate for phytohemagglutinin-stimulated peripheral blood lymphocytes and for methotrexate-resistant (R) and methotrexate-sensitive (S) sublines of CCRF-CEM. Either re...

Introduction:- Plantar fasciitis is the most common cause of heel pain. It a self-limiting condition. If causative factors are not addressed properly, it becomes chronic plantar fasciitis. Objectives:- The study aimed to evaluate efficacy 15 % hypertonic dextrose (treatment group) in treatment through comparison with cocktail group (control group). Design:- In this prospective controlled, rando...

The effects of the antiestrogen tamoxifen (TAM) on the growth of two hormone-sensitive human tumors have been examined in athymic mice. The endometrial tumor, EnCalOl, was stimulated to grow by TAM either alone or when combined with estradiol. This contrasted with the nonstimulation of the breast tumor, MCF-7, by TAM alone and the antago nist action of TAM on estradiol-stimulated growth of MCF-...

Data envelopment analysis (DEA) is a methodology for measuring the relative efficiency of decision making units (DMUs) which ‎consume the same types of inputs and producing the same types of outputs. Believing that future planning and predicting the ‎efficiency are very important for DMUs, this paper first presents a new dynamic random fuzzy DEA model (DRF-DEA) with ‎common weights (using...

Aims—To investigate the expression of â-catenin in non-small-cell lung cancer (NSCLC) and its clinical significance. Methods—101 patients were surgically treated for NSCLC by lobectomy or pneumectomy with systematic lymph node dissection. Follow up was available in all patients, ranging from 24 to 110 months. Immunostaining of tissue sections from primary tumours and (when present) their lymph ...

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A one-parameter symplectic group {e}t∈R derives proper canonical transformations on a Boson Fock space. It has been known that the unitary operator Ut implementing such a proper canonical transformation gives a projective unitary representation of {e}t∈R and that Ut can be expressed as a normal-ordered form. We rigorously derive the self-adjoint operator ∆(Â) and a phase factor e i ∫ t 0 τ Â (s...