One of the important challenges in geological storage of CO2 is predicting, monitoring, and managing the risk of leakage from natural and artificial pathways such as fractures, faults, and abandoned wells. The risk of leakage arises from the buoyancy of free-phase mobile CO2 (gas or supercritical fluid). When CO2 dissolves into formation brine, or is trapped as residual phase, buoyancy forces a...

PURPOSE: For poorly soluble, highly permeable (Class II) drugs, such as indomethacin, the rate of oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Therefore together with the permeability, the solubility and dissolution behaviour of a drug are key determinants of its oral bioavailability. The object of the present study is to increase dissolution rate o...

A long-duration pumping test performed in the conduit of a mixed flow karst system (MFKS) is analyzed and interpreted. It constitutes a unique experiment of catchment wide response of a karst system, with drawdowns measured both in the pumped conduit and in the matrix. A modeling approach is proposed for this interpretation. The developed double continuum model consists of two reservoirs karst ...

v Page Introduction Geologic Setting Hydrologic Setting Hypogenic Speleogenesis Coffee Cave Discussion Conclusions Acknowledgements IV. CASTILE EVAPORITE KARST POTENTIAL MAP OF THE GYPSUM PLAIN, EDDY COUNTY, NEW MEXICO AND CULBERSON COUNTY, TEXAS: A GIS METHODOLOGICAL COMPARISON Abstract Introduction Geologic Setting Field Studies GIS Analyses Discussion Conclusions Acknowledgements V. EPIGENE ...

Karst ecosystems are fragile and are in many regions degraded by anthropogenic activities. Current management of degraded karst areas focuses on aboveground vegetation succession or recovery and aims at establishing a forest ecosystem. Whether progressive succession of vegetation in karst areas is accompanied by establishment of soil biota is poorly understood. In the present study, soil microb...

Poor aqueous solubility is a major challenge for the drug development process, and many strategies have been developed to combat this problem. Cocrystals have gathered much interest in the recent years, due to their ability to enhance drug solubilities by orders of magnitude. However, highly soluble cocrystals tend to undergo rapid solution mediated transformation back to less soluble drug form...

With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch gly...

extended abstract 1. introduction karst classification is carried out in order to better investigate karsts. it plays a fundamental role in distinguishing and recognizing them. today, the implementation of development projects without the appreciation of karst classification and recognition seems a difficult task. field studies, topographic maps, satellite images, aerial photographs and geologi...