We analyze the equilibrium behavior of deterministic haploid mutation-selection models. To this end, both the forward and the time-reversed evolution processes are considered. The stationary state of the latter is called the ancestral distribution, which turns out as a key for the study of mutation-selection balance. We find that the ancestral genotype frequencies determine the sensitivity of t...

OBJECTIVES/HYPOTHESIS Surgical advancements rely heavily on validated animal models. The New Zealand White (NZW) rabbit is a widely used model for airway research, including regenerative medicine applications. Currently, the biomechanical properties of the normal rabbit trachea are not known. Our objective was to define these properties to assist in the standardization and understanding of futu...

the dynamic response of the railway under accelerated moving load using dynamic green function is presented in this paper. for this purpose, an exact and direct modeling technique is introduced for the railway modeling as the damped euler-bernoulli beam on the partial winkler foundation with arbitrary boundary conditions subjected to the moving load. the effects of the elastic coefficient of wi...

PURPOSE Maximum oxygen uptake (VO2max) is known to be influenced by life-style factors, such as exercise and smoking. We aimed to further test the hypothesis that, besides these, work form also contributes to increase VO2max among workers. METHOD Three thousand six hundred and forty eight male workers with age 38.3 +/- 12.1 and 1,575 female workers with age 35.6 +/- 11.1, ranging from 20-year...

Clostridium thermocellum is known to produce the cellulosomes with efficient plant cell wall degradation ability. To bring out the maximum cellulolytic ability of the cellulosomes, it is necessary to eliminate the end product inhibition by cellobiose. Combinations of β-glucosidases from thermophilic anaerobic bacteria and Aspergillusniger and C.thermocellum S14 cellulosomes were evaluated for o...

The goal of any load-management program is to maintain, as nearly as possible, a constant level of load, thereby allowing the system load factor to approach 100%. The important bene®ts of load management are reduction in maximum demand, reduction in power loss, better equipment utilisation and saving through reduced maximum demand charges. Load shifting, one of the simplest methods of load mana...

In this paper, finding the maximum load carrying capacity of mobile manipulators for a given two-end-point task is formulated as an optimal control problem. The solution methods of this problem are broadly classified as indirect and direct. This work is based on the indirect solution which solves the optimization problem explicitly. In fixedbase manipulators, the maximum allowable load is limit...

In this paper, an algorithm is proposed to improve the Maximum Load Carrying Capacity (MLCC) of exible robot manipulators. The maximum allowable load which can be achieved by a exible manipulator along a given trajectory is limited by the joints' actuator capacity and the end e ector accuracy constraint. In an open-loop approach, the end e ector deviation from the prede ned path is signi cant a...