A major concern affecting the efficient use of carbon fibre reinforced composite laminates in the aerospace industry is the low velocity impact damage which may be introduced accidentally during manufacture, operation or maintenance of the composite structures. It is widely reported that the contact behavior of composite laminates under low-velocity impact can be obtained under quasi-static loa...

Molecular damage of DNA plays an important role in the cell killing and several anti-neoplastic agents exert their cytotoxic effects by inducing DNA damage in the cancer cells. DNA damaging effect of various concentrations of berberine chloride (BCL), an isoquinoline alkaloid was studied in HeLa cells by alkaline comet assay. The DNA damage has been expressed as olive tail moment (OTM). Incubat...

MULTI-OBJECTIVE OPTIMIZATION OF BLAST SIMULATION USING SURROGATE MODEL Toshihiro Tsuga, M.S. George Mason University, 2007 Thesis Director: Dr. Rainald Löhner A multi objective optimization approach using a Kriging model coupled with a Multi Objective Genetic Algorithm (MOGA) is applied to a blast damage maximization problem composed of two objectives, namely number of casualties and damage to ...

Whether target organ damage is associated with blood pressure (BP) variability independent of level remains debated. We assessed these associations from 10-minute beat-to-beat, 24-hour ambulatory, and 7-day home BP recordings in 256 untreated subjects referred to a hypertension clinic. BP variability indices were variability independent of the mean, maximum-minimum difference, and average real ...

The maximum office systolic blood pressure (SBP) has been shown to be a strong predictor of cardiovascular events, independently of the mean SBP level. However, the clinical implications of maximum home SBP have never been reported. We investigated the association between the maximum home SBP and target organ damage (TOD). We assessed the left ventricular mass index (LVMI) and carotid intima-me...

Components for off-road bicycles including handlebars continue to be recalled with regularity because of problems with structural failure as a result of high cycle fatigue in the off-road environment. The objectives of this study were to 1) devise a method for determining the point on the handlebar cross section that experiences the maximum cumulative damage when the handlebar is subjected to l...

Cold/hypothermic induced longevity (CHIL) increases maximum lifespan, but the acute effects of CHIL on senescence, herein defined as the acceleration in mortality rate with age, have not been examined. Furthermore, dietary restriction (DR) also increases maximum lifespan, but the effect of DR on senescence remains controversial. Here, we demonstrate that in C. elegans, both DR and CHIL signific...

When an extreme earthquake occurs, it is essential to detect the severe structural damage that affect the structural safety immediately. This paper proposes a method for quick earthquake damage detection/evaluation of reinforced concrete bridge columns. An intelligent sensor unit is developed that captures changes in the natural period of a bridge column by FFT of response acceleration recorded...

This paper investigates the behaviour of C-shaped and L-shaped angle shear connectors embedded in solid concrete slabs. An effective finite element model is proposed to simulate the push out tests of these shear connectors that encompass nonlinear material behaviour, large displacement and damage plasticity. The finite element models are validated against test results. Parametric studies using ...

Two ways to deduce the equivalence of field equations general relativity and principle maximum force $c^4/4G$ - or equivalent power $c^5/4G$ are presented. A simple deduction inverse square gravity directly from arises. Recent apparent counterarguments refuted. New tests in astronomy, cosmology, electrodynamics, numerical gravitation quantum proposed.