A series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4H-1,2,4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4H-1,2,4-triazole (5f) was the most active one and also had...

In order to study the influence of the length of the amino acid chain of N,N-phthaloyl-amino acid amides as analogues of the former anticonvulsant taltrimide on the seizure-antagonizing activity glycine, beta-alanine and gamma-aminobutyric acid (GABA) derivatives were synthesized. The corresponding taurine derivatives were also included. Generally, the glycine-derived amides showed a higher act...

Maximal electroshock seizures (MES) in albino rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract. The ethanolic leaf extract of Vitex-negundo was administered orally in graded doses (250, 500 and 1000 mg/kg p.o) in both the experimental models and the effects were compared with diphenylhydantoin in MES meth...

teucrium polium (labiatae) is a plant that widely grows in iran. some of species of teucrium are used for a considerable range of actions in traditional medicine and t. polium has frequently been used as anticonvulsant. in this study, we investigated the protective effects of t. polium ethanolic aqueous extracts and related fractions on seizures induced by pentylenetetrazole (ptz) and maximal e...

A series of new 2-[(1-substituted phenylethylidine) hydrazine]-N-phenyl-1H-benzo[d]imidazole-1-carbothioamides (4a-n) were designed and synthesized to have the pharmacophoric elements essential for anticonvulsant activity. The key step in the synthesis of the title compounds involves the reaction of 2-mercaptobenzimidazole with hydrazine hydrate, substituted acetophenones and phenylisothiocyana...

The alcoholic extract of Achyranthes bidentata (AAB) has been studied for analgesic, anticonvulsant and CNS depressant activities in animal models. Analgesic activity was studied using acetic acid-induced writing test for assessing peripheral analgesic effect and tail immersion test for central analgesic effect. Anticonvulsant activity was performed by maximal electroshock induced convulsions; ...

The incomplete seizure control with frequent adverse effects of current anticonvulsant drugs and the importance of semicarbazones, quinazolines and 2,5-disubstituted 1,3,4-thiadiazoles as anticonvulsant pharmacophore prompted us to carry out synthesis of three novel series of semicarbazones containing 1,3,4-thiadiazole and quinazoline ring. The chemical structures of these compounds were elucid...

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world.Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In thispaper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3,5-dicarboxamides was performed.Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetr...

Introduction: the plant Mucuna pruriens is traditionally used in Indian system ofmedicine for therapy of several neurological disorders. Chemical investigationson have established presence levodopa and tryptamine which areresponsible treating disorders like Parkinsonism. Objective:the objective this research was to scientifically explore ascertain its antiepilepticand anxiolytic activity precli...