Microbial biofilm development is observed on virtually all submerged surfaces in natural and industrial environments. Biofilms are also observed at interfaces as pellicles, or in the bulk of aquatic environments as flocs or granules [1, 2]. A biofilm is a complex structure made of aggregates of microbial cells within a matrix of extracellular polymeric substances (EPS) (Figure 1). The matrix st...

Karawajczyk, M. 2000. Mechanisms of granule protein mobilization in blood eosinophils. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicin 951 p.60 Uppsala. ISBN 91-554-4799-6. Serum levels of the eosinophil granule proteins ECP, EPO and EPX, which are stored in the matrix of specific granules, were shown to correlate with the course of d...

The objective of the present investigation was to develop and evaluate sustained release matrix tablets of prochlorperazine maleate employing different types and levels of hydrophilic matrix agents namely hydroxyl propyl methyl cellulose (HPMC), carbopol and combination of these polymers by wet granulation technique. Prior to compression process, the prepared granules were evaluated for its flo...

A granular system consisting of ferromagnetic single-domain Fe particles in an antiferromagnetic FeCl2 matrix was prepared by coevaporation in an ultra-high vacuum environment. The structural and magnetic properties were investigated by Xray diffractometry and superconducting quantum interference device magnetometry, respectively. The heterostructure combines the properties of superparamagnetic...

The supramolecular conformation that keeps mucins interconnected in the mucus gel matrix is still uncertain. In the granule, a Ca-bonded matrix keeps mucus condensed. Upon exocytosis, Na/Ca exchange removes Ca bonds, triggering characteristic polymer gel phase transition and massive swelling (1). Failure to remove Ca by increased extracellular Ca inhibits mucus hydration (2). Transepithelial mo...

Amorphous phosphate granules are present in vertebrate and invertebrate organisms. The functions attributed to these structures depend on their mineral contents and organic matrix composition. In the present study we have determined zinc concentrations in the hepatopancreas of the crab Ucides cordatus from regions contaminated with zinc, and the elemental composition of hepatopancreal phosphate...

Isolated rat liver mitochondria were incubated in vitro under conditions supporting the massive accumulation of calcium and phosphate. Samples were embedded, thin sectioned, and examined in the electron microscope. The intramitochondrial distribution of insoluble or structure-bound mineral substances was studied by electron microscopy coupled with recently developed techniques of high resolutio...

The localization of three known alpha-granule proteins, thrombospondin (TSP), von Willebrand factor (vWF), and fibrinogen (Fg) has been studied in human megakaryocytes (MK) by immunofluorescence and immunoelectron microscopy. For this study, highly purified populations of MK were prepared from human bone marrow either by counterflow centrifugal elutriation or by cell culture from normal subject...

Hermansky-Pudlak Syndrome type-1 (HPS-1) is an autosomal recessive disorder caused by mutations in HPS1 which result in reduced expression of the HPS-1 protein, defective lysosome-related organelle (LRO) transport and absence of platelet delta granules. Patients with HPS-1 exhibit oculocutaneous albinism, colitis, bleeding and pulmonary fibrosis postulated to result from a dysregulated immune r...

In this study, the influence of matrix structure and viscosity was investigated to gain insight into mechanisms sandiness perception. Granules two types resistant starch (RS II III) were used as edible particles different size type II, D4,3 = 21.25 μm; RS III 44.03 μm). First impact adding at levels (1.5 3%) on rheology (flow behaviour) sensory properties (ranking test) custards determined. Sec...