To help us identify appropriate techniques and laboratories for measuring hormones, we studied the variability and reproducibility of assay measurements of androstanediol glucuronide, androstenedione, dehydroepiandrosterone (DHEA), DHEA sulfate, dihydrotestosterone, testosterone, androstanediol, androsterone glucuronide, and androsterone sulfate for five men. Four sets of two aliquots from each...

PURPOSE The aim of the study was evaluation of dehydroepiandrosterone sulphate (DHEA-S) serum concentration in elderly women and determining interdependence between DHEA-S levels and occurrence of diseases typical for this period of life. MATERIAL AND METHODS The study was conducted on 103 elderly women (mean age 70.7 +/- 7.3 years). The control group consisted of 25 young and healthy women (...

Background: The aim of this study is to analyze the correlation ovarian volume and clinical laboratory parameters polycystic ovary syndrome (PCOS) in Korean women. Methods: Two hundred thirty-three patients aged between 20 40 years with PCOS diagnosis January 2014 June 2020 at Pusan National University Hospital, Busan, Republic Korea, were included retrospective observational using previously r...

The marked decline in serum dehydroepiandrosterone (DHEA) with age is believed to play a role in health problems associated with aging, these health issues being potentially preventable or reversible by the exogenous administration of DHEA. In the present study, liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) and gas chromatrography/mass spectrometry (GC/MS) were used to me...

Dehydroepiandrosterone (DHEA) and the dehydroepiandrosterone sulfate (DHEA-S) are steroids produced mainly by the adrenal cortex. There is evidence from both human and animal models suggesting beneficial effects of these steroids for obesity, diabetes mellitus, hypertension, and osteoporosis, conditions associated with the post-menopausal period. Accordingly, we hypothesized that DHEA supplemen...

OBJECTIVE Changes in serum neurosteroid levels have been reported in stress-related disorders such as anxiety and depression, but not in patients with obsessive-compulsive disorder (OCD). We thus investigated such changes in patients with OCD. METHODS We compared the serum levels of progesterone, pregnanolone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEA-S), cortisol a...

BACKGROUND Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effe...

BACKGROUND This study aimed to evaluate some of the major risk factors of myocardial infarction including dehydroepiandrosterone sulfate in patients with premature myocardial infarction (age <50 years old) and myocardial infarction (age ≥50 years). METHODS This is a parallel case-control study on 50 premature myocardial infarction patients and 50 myocardial infarction patients. We also recrui...

The effects of chronic renal failure on the pituitary-testicular axis of 31 males, aged 11.7 to 20.0 yr (mean, 16.0 yr) were studied. Nine patients not on hemodialysis (group I) had serum creatinines between 2.5 and 8.0 mg/dl, 10 patients were on hemodialysis (group II) and 12 patients had received a renal transplant (group III). The Tanner stage of pubertal development was delayed relative to ...

Abstract Objective: The investigation of adrenal steroids and testosterone levels in male autistic children will, undoubtedly, help to elucidate the pathogenetic implication these hormones development autism their role as risk factors. objective this case-control study is explore potential involvement pathogenesis autism. Method: Serum total (TT), dehydroepiandrosterone (DHEA) sex-hormone bindi...