Presence of mast cell precursors in the mouse peritoneal cavity was demonstrated, and the precursors were characterized. When a cell suspension, containing mast cell precursor(s), was directly injected into the skin of genetically mast cell-deficient WBB6F1 (WB X C57BL/6)-W/Wv mice, a cluster composed of approximately 2,000 mast cells appeared at the injection site. By determining the proportio...

Initial work up of a mast cell tumor (MCT)will involve diagnosis by FNA and staging. The initial staging performed will depend on the index of suspicion that the mass is a grade II or III MCT and clinician’s preference. Cytology is generally diagnostic for MCT. However, an incisional biopsy to determine grade is recommended in some cases. The histological grade may be important to determine in ...

This work presents a parametric-solver algorithm for estimating atmospheric stability and friction velocity from floating Doppler wind lidar (FDWL) observations close to the mast of IJmuiden in North Sea. The focus study was two-fold: (i) examine sensitivity computational retrieved variables derived classes (the latter through confusion-matrix theory), (ii) present data screening procedures FDW...

Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells towa...

Mast cell degranulation is a highly regulated, calcium-dependent process, which is important for the acute release of inflammatory mediators during the course of many pathological conditions. We previously found that Synaptotagmin-2, a calcium sensor in neuronal exocytosis, was expressed in a mast cell line. We postulated that this protein may be involved in the control of mast cell-regulated e...

The function of mast cells as effector cells in allergy has been extensively studied. However, increasing insight into mast cell physiology has revealed new mast cell functions and has introduced mast cells as key players in the regulation of innate as well as adaptive immunity. For example, mast cells have recently been found to express Toll-like receptors (TLRs), which enable them to particip...

Mast cells, immune effector cells produced from bone marrow cells, play a major role in immunoglobulin E-mediated allergic responses. Ionizing radiation affects the functions of mast cells, which are involved in radiation-induced tissue damage. However, whether ionizing radiation affects the differential induction of mast cells is unknown. Here we investigated whether bone marrow cells of X-irr...

In an attempt to obtain an antiserum that would bring about widespread destruction of mast cells in the rat, rabbits were immunized with mast cells isolated from the peritoneal cavities of rats. Striking evidence of anti-mast cell activity was indicated in vivo by mast cell disruption and in vitro by positive interfacial precipitin tests of the serum from rabbits so treated. The time course of ...

Mast cells are mobile granule-containing secretory cells that are distributed preferentially about the microvascular endothelium in oral mucosa and dental pulp. The enzyme profile of mast cells in oral tissues resembles that of skin, with most mast cells expressing the serine proteases tryptase and chymase. Mast cells in oral tissues contain the pro-inflammatory cytokine tumour necrosis factor-...

Zarnegar, B. 2016. Mechanisms triggering the recruitment of mast cell progenitors to the lung and regulation of mast cell degranulation. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1274. 51 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9746-0. Mast cells stem from the bone marrow and migrate via the blood as mast cell progenitors. Upon ar...