The field of cachexia and muscle wasting research has started to move, slowly but steadily, and large and small companies alike are increasing their efforts into the development of new drug therapies for cachexia, sarcopenia and frailty. Recent research has focused on novel screening tools and biomarker research to enable an early diagnosis of wasting, but also on the pathophysiological underst...

Hadal trenches are considered to act as depocenters for organic material, although pathways the material transport and deposition rates poorly constrained. Here we assess focusing, accumulation of carbon in four hadal trench systems underlying different surface ocean productivities; eutrophic Atacama Kuril-Kamchatka trenches, mesotrophic Kermadec oligotrophic Mariana Trench. The study is based ...

Proteineenergy malnutrition has been proposed to be a cause of refractory anemia that accompanies the malnutritioneinflammation complex (or cachexia) syndrome in dialysis patients. Malnutritioneinflammation complex syndrome and the obesity paradox are also the main etiology for “reverse epidemiology” of cardiovascular risk factors and outcomes in dialysis patients. However, in some dialysis pat...

AIM To identify patients with end-stage renal disease treated by peritoneal dialysis (PD) who had zero body fat (BF) as determined by analysis of body composition using anthropometric formulas estimating body water (V) and to compare nutritional parameters between these patients and PD patients whose BF was above zero. METHODS Body weight (W) consists of fat-free mass (FFM) and BF. Anthropome...

BACKGROUND Cancer cachexia (cancer-induced muscle wasting) is found in a subgroup of cancer patients leaving the patients with a poor prognosis for survival due to a lower tolerance of the chemotherapeutic drug. The cause of the muscle wasting in these patients is not fully understood, and no predictive biomarker exists to identify these patients early on. Skeletal muscle loss is an inevitable ...

Glucocorticoids are highly conserved fundamental regulators of energy homeostasis. In response to stress in the form of perceived danger or acute inflammation, glucocorticoids are released from the adrenal gland, rapidly mobilizing energy from carbohydrate, fat and protein stores. In the case of inflammation, mobilized protein is critical for the rapid synthesis of acute phase reactants and an ...