Malignant tumor originated from external auditory canal (EAC) is very rare with an annual incidence of around 1 per million. Pathologically, squamous cell carcinoma is incidentally most common, and adenoid cystic carcinoma, basal cell carcinoma, and melanoma follow in decreasing order. Due to the rarity of malignant tumor of EAC, there is no widely accepted treatment modality yet. But basal cel...

Due to acute and particularly chronic postirradiation complications in radiotherapy of the prostate, the dose application, and consequently also the irradiation effect, are restricted. The incidence and grade of acute and chronic complications depend upon the dose and volume of the surrounding organs involved in the irradiation area.1-4 As the restrictions on dose application should in no way b...

The reliability index is an important reliability parameter that is necessary for the development of reliability-based geotechnical design. Both the factor of safety (FS) and the reliability index (β) represent safety margin of structures against either failure or limit state. In this study, the reliability index is analyzed and evaluated in reference to the factor of safety currently adopted i...

10.2217/14750708.2.2.167 © 2 part of Inhaled corticosteroids are recommended first-line therapy for asthma of all severities. Concerns regarding local and systemic side effects can influence adherence, and subsequently, efficacy and long-term asthma control. Ciclesonide is a novel inhaled corticosteroid with an improved therapeutic margin – its efficacy is similar to that of other inhaled corti...

Evaluations of studies for four well-known human developmental toxicants clearly suggest that a margin of exposure of 1/100th the NOAEL for the most sensitive animal species tested provides adequate safety for the human conceptus. The lowest reported human teratogenic exposures occurred at doses at least one log above the estimated "safe" or acceptable daily exposure based on the most sensitive...

We analyze the determinants of government debt under the twin assumptions that governments have limited horizons and default only when government income falls short of debt service requirements. We derive a government’s maximum sustainable debt ratio, that is, the debt ratio chosen by a myopic government whose horizon does not extend beyond its current term in office. Maximum sustainable debt v...

Most criticality safety calculations are performed using Monte Carlo techniques because of Monte Carlo’s ability to handle complex three-dimensional geometries. For Monte Carlo calculations, the more histories sampled, the lower the standard deviation of the resulting estimates. The common intuition is, therefore, that the mo re histories, the better; as a result, analysts tend to run Monte Car...