OPC-14523 (OPC; [1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate)] is a novel compound with high affinity for and 5-HT1A receptors as well as for the 5-HT transporter. OPC has previously been shown to produce antidepressant-like effects in animal models of depression. This project set out to determine the effect of OPC on serotonergic neur...

and Introduction Introduction The use of herbal remedies has been around for centuries and their use in both western and eastern societies are increasing. Patient surveys have reported that 12% of Americans, 12% of Australians, and 4.8% of patients in the UK use herbal remedies. The World Health Organization (WHO) estimates that up to 80% of the world's population still depend on herbal medicin...

Treatment-resistant depression (TRD) is a prevalent, disabling, and costly condition affecting 1%–4% of the U.S. population. Current approaches to managing TRD include medication augmentation (with lithium, thyroid hormone, buspirone, atypical antipsychotics, or various antidepressant medications), psychotherapy, and ECT. Advances in understanding the neurobiology of mood regulation and depress...

Many poisoned patients are treated with no laboratory help other than general clinical chemistry and haematology. However, some emergency toxicological analyses that could influence immediate patient management such as ethanol, iron, lithium, paracetamol (acetaminophen), and salicylates should be provided at hospitals with emergency departments on an urgent (24 h, maximum 2 h turnaround) basis....

Several lines of evidence have challenged the assumption that sleep is a whole brain phenomenon. The idea of covert rapid-eye-movement sleep (REMS) processes (Nielsen, 2000) suggests that activity in different areas of the brain participate in different behavioral states at once. Posited covert REMS processes are consistent with a model of brain organization that begins at a local, neuronal gro...