In this double blind crossover study we assessed the bioequivalence of 200 mg enteric coated sodium valproate tablets manufactured by Roozdarou with 200 mg enteric coated sodium valproate (Orlept) manufactured by Desitin, Germany. Twelve healthy male volunteers were administered a single dose of 600 mg sodium valproate manufactured by Roozdarou, followed by a similar dose of Orlept, 2 weeks...

... When once the engine shall have been constructed, the difficulty shall ha1)e been reduced to the making out of cards; but as these are merely the translation of algebraical formulae, it will, by means of some simple notations, be easy to consign the execution of them to a workman. Thus, the whole intellectual labour will be limited to the preparation of the formulae, which must be adapted f...

To the editor: Kilander et al. (2010) [1] have previously reported that in some cases of patients with severe or fatal pandemic influenza A(H1N1), an amino acid substitution from aspartic acid to glycine occurs at position 222 (D222G) of the HA1 subunit of haemagglutinin (HA). In their study 11 (18%) of 61 patients with severe disease had the mutation, in contrast to 0 of 205 patients with mild...

1 ECS University of Westminster, London, HA1 3TP, UK e-mail: [email protected] 2 Warrane College, University of New South Wales, Kensington, 1465, Australia e-mail: [email protected] 3 Department of Mathematics, Vellalar College for Women, Erode 638 009, Tamilnadu, India e-mail: [email protected] 4 Centre of Biomedical Engineering, Bulgarian Academy of Sciences P.O.Box 12, ...

Introduction Recently, fructose consumption has been suggested to be one of the environmental factors contributing to the development of insulin resistance, obesity, dislipidemia and other abnormalities of the metabolic syndrome. Aim Herbal extracts with established therapeutic efficiency in patients with obesity and diabetes have been traditionally used in Bulgarian ethnomedicine.This study in...

The antigenic variability of influenza viruses has always made influenza vaccine development challenging. The punctuated nature of antigenic drift of influenza virus suggests that a relatively small number of genetic changes or combinations of genetic changes may drive changes in antigenic phenotype. The present study aimed to identify antigenicity-associated sites in the hemagglutinin protein ...

Habitat loss and fragmentation negatively impact the size and diversity of many natural populations. Woodland amphibians require connected aquatic and terrestrial habitats to complete their life cycle, and often rely on metapopulation structure for long-term persistence. Wetland loss and deforestation fragment amphibian populations, which may result in population isolation and its negative effe...

A dramatic rise in the frequency of resistance to adamantane drugs by influenza A H3 viruses, associated with a single amino acid replacement in the viral matrix M2 protein, has occurred in multiple countries worldwide in recent years. We investigated the frequency of adamantane-resistant influenza A H3 viruses in Argentina during the period 2001-2007. We used reverse transcription followed by ...

ADAMS accession number for each document referenced in this notice (if that document is available in ADAMS) is provided the first time that a document is referenced. SUPPLEMENTARY INFORMATION: The proposed amendment would have revised the facility technical specifications pertaining to change the Emergency Action Levels (EALs) for North Anna Power Station (NAPS) and Surry Power Station (SPS). S...

Mobile homes are often perceived as a cheap housing alternative of last resort. This paper reviews the history of the mobile home from its trailer house beginnings to its present manufactured home status. Manufactured homes (HUD Code mobile homes) located in manufactured home land lease parks are an affordable and preferred housing choice of many housing consumers. Furthermore, manufactured hou...