ion/Flexibility (Wisconsin Card SortingTest; Heaton et al, 1993) The percentage of perseverative errors was used as the central parameter. Statistical analyses Frequency counts and descriptive statistics were calculated for initial basic symptoms, observed and self-perceived psychopathology. Differences in initial psychopathology between those patients at risk who experienced a transition to ps...

Motivated by recent applications of the Mann–Whitney U test to large data sets we took a critical look at current methods for computing its significance. Surprisingly, we found that the two fastest and most popular tools for exact computation of the test significance, Dinneen and Blakesley’s and Harding’s, can exhibit large numerical errors even in moderately large datasets. In addition, anothe...

Obesity is frequently associated with insulin resistance. Recently an important role of the cytokine tumor necrosis factor-alpha in mediating insulin resistance of obesity through its overexpression in fat tissue has been reported. In order to examine the relation of insulin resistance to obesity and to serum neopterin, as a parameter of immune activation, we studied 1234 otherwise healthy outp...

In a prospective, randomised trial of 81 patients with fractures of the ankle of AO types A, B and C we compared two regimes of postoperative management after internal fixation. The patients were mobilised either non-weight-bearing with crutches or weight-bearing in a below-knee walking plaster. We found a temporary benefit in subjective evaluation only (65 v 50 points, Mann-Whitney test, cft, ...

The t-test is as defined in the previous lecture. It has slope 1/σ. The Mann-Whitney test rejects if 1 nm ∑ i,j I(Xi ≤ Yj) is large. Note. The Mann-Whitney statistic has a relationship with the area under the ROC curve (AUC) for classification algorithms with a tunable parameter. The ROC plot has one axis for proportion of false positives and one axis for proportion of true positives; as we mov...

We reviewed 87 patients who underwent revision reconstruction of the anterior cruciate ligament. The incidence of meniscal tears and degenerative change was assessed and related to the interval between failure of the primary graft and revision reconstruction. Patients were divided into two groups: early revision surgery within six months of graft failure, and delayed revision. Degenerative chan...

BACKGROUND The objective of this study was to assess the concentration of metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) in peripheral circulation and their mRNA expression in peripheral blood mononuclear cells (PBMCs) in patients with CAP caused by M. pneumoniae. MATERIAL/METHODS We prospectively analyzed MMPs in 40 hospitalized patients with M. pneumoniae CAP on admission, and ...