Manganese homeostasis involves coordinated regulation of specific proteins involved in manganese influx and efflux. However, the proteins that are involved in detoxification/efflux have not been completely resolved nor has the basis by which they select their metal substrate. Here, we compared six proteins, which were reported to be involved in manganese detoxification/efflux, by evaluating the...

Perception and response to nutritional iron availability by bacteria are essential to control cellular iron homeostasis. The Irr protein from Bradyrhizobium japonicum senses iron through the status of heme biosynthesis to globally regulate iron-dependent gene expression. Heme binds directly to Irr to trigger its degradation. Here, we show that severe manganese limitation created by growth of a ...

There are a number of minor inorganic elements constantly found in animal tissues whose function, or even necessity, is still in question. Among such elements are manganese, zinc, cobalt, and nickel. In the last few years the necessity for copper as a supplement to iron in hemoglobin building has been firmly established (1). After this relationship had been demonstrated a number of investigator...

Manganese and ADHD A study published in Neurotoxicology has generated discussion because it shows a link between high levels of manganese (Mn) given to rats during infancy and the development of behavioral problems similar to Attention Deficit Hyperactivity Disorder. Mn is an essential element and is currently required by law in infant formulas, but can be neurotoxic at high levels. Recent repo...

The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...

Lethargy is a frequent and important clinical feature of anaemia; however, it does not absolutely correlate with the severity of anaemia. Manganese is efficiently absorbed through the gastrointestinal tract via divalent metal transporter 1 (DMT1), which is also responsible for iron transport. DMT1 is upregulated in iron deficiency (ID). Increased manganese concentrations are reported in ID anae...

the preparation of nanostructure type manganese oxide and cobalt oxide materials with the smallest particle size is reported here. the nanorod manganese oxide and cobalt oxide nanotube were prepared via a sol-gel reaction in reverse micelles from kmno4 and cocl2 with respectively source at room-temperature. the structure and surface morphology of the obtained manganese oxide were studied by mea...

There is some evidence supporting the reduced activity of integrins following chronic administration of morphine. This reduction might play a role in morphine tolerance development. Manganese binds to the extracellular domain of integrins and makes them to be activated. The effect of integrins activation using manganese on tolerance development to the analgesic effect of morphine was investi...

Both ferromagnetic and ferroelectric properties were observed in two enantiomerically pure nanoscale manganese cluster complexes supported by chiral Schiff base ligands, each of which comprises a 22-nucleus mixed-valence manganese(II/III) supratetrahedral cluster cation and an equilateral-triangle trinuclear manganese(III) cluster anion with C(3) symmetry.