Malignant mesotheliomas are aggressive cancers that occur in the thin layer of tissue covers most commonly linings chest or abdomen. Though cancer itself is rare and deadly, early diagnosis will help with treatment improve outcomes. Mesothelioma usually diagnosed later stages. Symptoms similar to other, more common conditions. As such, predicting diagnosing mesothelioma essential starting for a...

Malignant pleural mesothelioma is the most common mesothelial malignancy, which arises from the malignant transformation of mesothelial cells that line the pleural cavity. Malignant pleural mesothelioma is a highly invasive disease with a very long latency and treatment is rarely effective, since only few patients survive more than one year after diagnosis (Carbone et al., 2007). Asbestos, a fi...

Malignant mesothelioma is an aggressive and therapy-resistant neoplasm arising from mesothelial cells. Evidence suggests that the major pathology associated with asbestos-induced mesothelioma is local iron overload. In the present study, we induced iron-induced mesothelioma in rats based on previous reports. Ten Wistar rats were given ferric saccharate and nitrilotriacetate i.p. for 5 days a we...

BACKGROUND Malignant pleural mesothelioma is a relatively uncommon disease, but the incidence is increasing and is expected to peak in many developed countries in the next two decades. The management of patients with malignant mesothelioma is controversial. Very few patients are suitable for any potentially curative treatment and the effectiveness of radical therapy with surgery, radiotherapy a...

Malignant mesothelioma of the epididymis is a very rare tumor. We report a case of a 33-year old male with a left hydrocele that presented for evaluation of infertility. Scrotal ultrasound revealed a left extratesticular mass. Final pathology revealed malignant mesothelioma involving the epididymis, with well differentiated epithelioid morphology. Metastatic workup was negative.

Inflammation is a key mediator in the development of malignant mesothelioma, which has a dismal prognosis and poor therapeutic strategies. Curcumin, a naturally occurring polyphenol in turmeric, has been shown to possess anticarcinogenic properties through its anti-inflammatory effects. Inflammasomes, a component of inflammation, control the activation of caspase-1 leading to pyroptosis and pro...

Although cisplatin and pemetrexed are key drugs in the treatment of malignant pleural mesothelioma, their drug-drug interactions, cross-resistance and resistance mechanisms in malignant pleural mesothelioma are not well understood. In the present study, the interaction of these 2 agents was determined by clonogenic assays followed by isobologram a...

Malignant mesothelioma or mesothelioma is a rare form of cancer that develops from transformed cells originating in the mesothelium, the protective lining that covers many of the internal organs of the body. It is directly linked to asbestos exposure, which acts as a carcinogen by initiating the carcinogenic process. Because of their shape, asbestos fibers can cross the membrane barriers inside...

The authors should be congratulated for their comprehensive review of prognostic factors in malignant pleural mesothelioma. Although the paper emphasizes the emergence of molecular and genetic biomarkers, which hold great promise for transforming the management of malignant mesothelioma, the authors also cite numerous studies of hard clinical indices that have prognostic significance in mesothe...

Malignant mesothelioma is a diffuse tumor arising in the pleura, peritoneum, or other serosal surface and is closely associated with asbestos exposure. An estimated 2,500 to 3,000 cases are diagnosed each year in the United States. Although there are individual case reports and small series detailing the clinical aspects of mesothelioma, few studies examine a large series of patients with malig...