The skin is a unique marker for malignancy as these cutaneous manifestation not only often precede the development of other symptoms, but also often cause patients to seek medical attention sooner than they would for other symptoms. Common cutaneous markers for malignancy include: acanthosis nigricans, carcinoid syndrome, Leser-Trelat sign, and necrolytic migratory erythema. Although these skin...

background: acanthosis nigricans (an) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. treatment of an is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. the goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for tre...

CRP was first described in 1927 by Gougerot and Carteaud and it occurs predominantly in young adults and teenagers, affecting the neck, upper trunk and axillae with cosmetically displeasing appearance. Recognition of CRP is usually difficult by clinicians, including dermatologist as it frequently appears as pityriasis versicolor or acanthosis nigricans resulting in delay in the diagnosis [2]. H...

A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology department with the diagnosis of acanthosis nigricans for investigation of an underlying malignancy. He was a smoker. A computed tomography scan of thorax revealed...