objective(s): sugar cane molasses is a commonly used ingredient in several food products. contrasting reports suggest that molasses may have potential adverse or beneficial effects on human health. however, little evidence exists that examines the effects of molasses on the different physiological systems. this study investigated the effects of sugar cane molasses on various physiological syste...

objective: the main objective of the current study was to observe the ameliorative effect of withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. materials and methods: in the present study, arsenic in the form of sodium arsenite was administered orally ...

OBJECTIVES There is limited data regarding the toxicity of methylcyclohexane, despite its wide use in rubber adhesives, paint diluents, and cleansing agents. This study aimed to verify the toxicity and influence on the reproductive system of methylcyclohexane after its repeated injection in Sprague Dawley (SD) rats. METHODS Methylcyclohexane was injected subcutaneously into male and female SD...

Panax ginseng is known to potentiate the immune system via its antioxidant properties. Cadmium as an environmental pollutant has destructive effects on body organs especially reproductive system. This study investigated of P. extract against cadmium-induced testicular toxicity in rats. In this experimental study, 50 male adult rats were randomly divided into 5 groups: A significant decrease was...

Background: The role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. This study was performed to evaluate the possible protective effect of vitamins E and C, against endosulfan-induced reproductive toxicity in rats. Methods: Fifty adult male Sprague–Dawley rats were randomly divided into five groups (n=10 each). The groups included a control receivin...

OBJECTIVE To investigate the effects of 3,4-dichloroaniline (3,4-DCA) on activities of testicle enzymes as biological markers in rats. METHODS Fifty male rats were randomly divided into 5 groups (n=10). One group was left untreated and used as a solvent control (administered orally by corn oil), while the other 4 groups were treated with 3, 4-DCA. Corn oil was used as a solvent, and 3,4-DCA w...

Exposure to pesticides could be one of the contributing cause to the falling sperm counts and rising levels of male infertility. Adverse effects of pesticides in the environment first received widespread attention in the 1960s. However, only recently it has been postulated that long term, low exposure of these chemicals are increasingly linked to human health effects such as immuno-suppression,...

Objective Indiscriminate use of synthetic pyrethroid insecticides, Cypermethrin (Cyp) and Deltamethrin (Del) have been reported to cause system toxicity in mammals including humans. The dietary antioxidants protects tissues and organs against insecticides/xenobiotic induced damage. In present study, we evaluated the effect of exposure of Cyp and Del and possible protective roles of curcumin and...

The present work investigated repeated dose and reproductive toxicity of Calebin A in Wistar rats. A study for assessing the mutagenic potential of Calebin A through an AMES test is also described. Calebin A was orally administered to groups of 10 male and/or 10 female Wistar rats each, assigned to three dose levels (20, 50 and 100 mg/kg/body weight) once daily for 90 consecutive days. None of ...

The utilization of safety biomarkers to predict the possibility of compound-related toxicity provides several advantages for drug discovery and development, especially at an early stage. The objectives of this study were to investigate the effects of male reproductive toxicants on protein expression profiles in the rat testes and to identify potential biomarker candidates. Four well-known repro...