Objective(s):This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. Materials and Methods: PM was prepared by boiling the dried slices of P. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. Eighteen Sprague Dawley adult...

The effect of ageing on CYP3A2, a male specific isoform, was examined in adult (9 months) and senescent (24 months) male rats. A significant decrease (65%) of CYP3A2-related activity (midazolam oxidation) was observed in all senescent rats. Half of these rats still express CYP3A2 suggesting that decreased activities in these rats are due to post-translational modifications. The other senescent ...

Citrullus colocynthis has been used to treat obesity and hyperlipidemia. Nanoparticles, due their nano size, phytochemical adsorption, improved systemic absorption high bioavailability, can potentially improve the bioactivity of C. colocynthis. The present research focused on studying effects green synthesized calcium oxide nanoparticles (CaONPs) from fruit extracts (CCFE) body weight, atheroge...

The Spontaneously Diabetic Torii (SDT) rat is a spontaneous animal model of non-obese Type 2 diabetes (T2D) resembling those of humans, established in 1997. I investigated the clinical features of the SDT rats. The time of onset of glucosuria was different between male and female SDT rats; glucosuria appeared at approximately 20 weeks of age in male rats and at approximately 45 weeks of age in ...

introduction: this study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats. methods: the mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. diazepam treated group received diazepam 30 minutes before intraden...

Acute and Subchronic Inhalation Toxicity of Chloroform in Rats and Mice: Tatsuya KASAI, et al. Japan Bioassay Research Center—In order to better characterize acute and subchronic toxicities of chloroform and to provide its basic toxicity data for risk assessment of humans exposed to chloroform in work and living environments, mice and rats of both sexes were exposed by inhalation to chloroform ...

Birth control measures available are primarily for women which hormonal supplements that increasing cancer risks and reproductive health issues. Male contraceptive options effective available, i.e. barrier methods vasectomy. Condoms failure-prone single-use, while a vasectomy is permanent sterilization method done surgically, reversion not always successful expensive. A promising oral male drug...

The paper aims at verifying the influence of supplemented spirulina on the form of erythrocytes and the content of hemoglobin of anaemic ICR male rats that have done exercises. The method adopted: scanning electronic microscope and full automated hematology analyzer are used to studying the influence of supplementing spirulina on the form of erythrocytes and the content of hemoglobin of rats. R...

During early ontogeny, stimuli that pose a threat to an animal change. Unrelated adult male rats may kill young rats, but infanticide ends around weaning. Predation, on the other hand, may increase during early ontogeny when rats begin to extend their activity range. We investigated the developmental course of two defensive responses, immobility and analgesia, in young rats exposed to an adult ...

Young rats become immobile when exposed to a potentially infanticidal adult male rat. Male-induced immobility declines during the preweaning period, paralleling the decrease in infanticidal threat. To investigate the neural substrates underlying the developmental change in immobility, male-induced expression of the immediate-early gene c-fos was assessed on postnatal days 7, 14 and 21. A huddle...