Myelin inhibitors, including MAG, are major impediments to CNS regeneration. However, CNS axons of DRGs regenerate if the peripheral branch of these neurons is lesioned first. We show that 1 day post-peripheral-lesion, DRG-cAMP levels triple and MAG/myelin no longer inhibit growth, an effect that is PKA dependent. By 1 week post-lesion, DRG-cAMP returns to control, but growth on MAG/myelin impr...

We present revised and improved mid-infrared Period-Luminosity (PL) relations for Large Magellanic Cloud (LMC) Cepheids based on double-epoch data of 70 Cepheids observed by Spitzer at 3.6, 4.5, 5.8 and 8.0 μm. The observed scatter at all wavelengths is found to decrease from ±0.17 mag to ±0.14 mag, which is fully consistent with the prediction that the total scatter is made up of roughly equal...

The polycondensation of tetrahydrofuran with maleic anhydride catalyzed by Maghnite-H+ (Mag-H) was investigated. Maghnite is a montmorillonite sheet silicate clay that is exchanged with protons to produce Maghnite-H [1]. It was found that the polymerization in bulk is initiated by Mag-H in the presence of acetic anhydride at 40 degrees C. The effects of the amounts of Mag-H and acetic anhydride...

The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA ac...

We report optical observations of the GRB 980329 error box which represent the second earliest detection of the GRB 980329 optical transient. We determine R = 23.7 ± 0.5 mag on 29.89 March, which is consistent with R = 23.6 ± 0.2 mag as reported by Palazzi et al. (1998) on 29.99 March. Based on extrapolations of the light curve we claim that the R-band magnitude of the GRB 980329 host galaxy sh...

Insulin/IGF-1 signaling (IIS) pathway is known to control growth, development and reproduction. Insulin-like peptide mediated body size plasticity in Drosophila melanogaster has been reported. Here, our studies showed that IIS pathway and nutrition regulate growth and maturation of the male accessory gland (MAG) in the red flour beetle, Tribolium castaneum. The size of MAG increased from day 1 ...

B cells encounter both soluble Ag (sAg) and membrane-associated Ag (mAg) in the secondary lymphoid tissue, yet how the physical form of Ag modulates B cell activation remains unclear. This study compares actin reorganization and its role in BCR signalosome formation in mAg- and sAg-stimulated B cells. Both mAg and sAg induce F-actin accumulation and actin polymerization at BCR microclusters and...

Invasion and metastasis are the main causes of treatment failure and death in breast cancer. Thus, novel invasion-based therapies such as those involving natural agents are urgently required. In this study, we examined the effects of magnolol (Mag), a compound extracted from medicinal herbs, on breast cancer cells in vitro and in vivo. Highly invasive cancer cells were found to be highly sensit...

Amyloid formation is associated with multiple amyloidosis diseases. Human calcitonin (hCT) is a typical amyloidogenic peptide, its aggregation is associated with medullary carcinoma of the thyroid (MTC), and also limits its clinical application. Magnolia officinalis is a traditional Chinese herbal medicine; its two major polyphenol components, magnolol (Mag) and honokiol (Hon), have displayed m...

The subcellular distribution in rat liver of a phospholipid identified as bis-(monoacylglyceryl) phosphate (bis(MAG)P) has been investigated. In liver from untreated animals, 48 % of bis(MAG)P was recovered in a crude mitochondrial fraction where it was enriched 2.8-fold over the homogenate in terms of protein. When liver from animals who had received Triton WR-1339 by injection 3 days earlier ...