نتایج جستجو برای: maf
تعداد نتایج: 1574 فیلتر نتایج به سال:
Adult body height is a quantitative trait for which genome-wide association studies (GWAS) have identified numerous loci, primarily in European populations. These loci, comprising common variants, explain <10% of the phenotypic variance in height. We searched for novel associations between height and common (minor allele frequency, MAF ≥5%) or infrequent (0.5% < MAF < 5%) variants across the ex...
We have used two-dimensional 1H NMR spectroscopy to determine the solution structures of the 4'-(hydroxymethyl)-4,5',8-trimethylpsoralen (HMT) furanside monoadducted (MAf) and the photoisomeric HMT interstrand cross-linked (XL) DNA oligonucleotide d(5'-GCGTACGC-3')2. The determination of the structure was based on total relaxation matrix analysis of the NOESY cross-peak intensities using the pr...
Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as k...
PURPOSE To determine which are the most sensitive tests, together with accommodative amplitude, to classify accommodative insufficiency (Al), we analyzed the relation between monocular estimated method (MEM) dynamic retinoscopy, monocular and binocular accommodative facility (MAF, BAF), and positive relative accommodation (PRA) with or without the presence of reduced amplitude of accommodation....
OBJECTIVE In multiple myeloma (MM), seven primary recurrent translocations involving the immunoglobulin heavy chain locus have been identified. One of the partner loci maps to 20q12 and involves the MAFB gene resulting in its ectopic expression. We attempt here to identify MAFB target genes in MM. MATERIALS AND METHODS We used an inducible system to upregulate MAFB in MM cell lines not carryi...
Currently, single-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) of >5% are preferentially used in case-control association studies of common human diseases. Recent technological developments enable inexpensive and accurate genotyping of a large number of SNPs in thousands of cases and controls, which can provide adequate statistical power to analyze SNPs with MAF <5%. Our pu...
As the use of internet based learning has seen a significant increase over the last decade, the topic of new model, methods and tools to support eLearning have been significant over the last ten years. In this paper, a multimedia application format (MAF) for e-Learning is proposed. The eLearning MAF shall meet various requirements which enable users to facilitate search, evaluation, acquisition...
Macrophages are a major component of the innate immune response, comprising the first line of defense against various intracellular pathogens, including Mycobacterium tuberculosis. In this report, we studied the factors that regulate growth of M. tuberculosis H37Rv in subpopulations of human monocyte-derived macrophages (MDMs). In healthy donors, M. tuberculosis H37Rv grew 5.6-fold more rapidly...
The objective of this study was to investigate potential associations between an individual's psychophysical maximum acceptable force (MAF) during pushing tasks and biomechanical tissue loads within the lumbar spine. Ten subjects (eight males, two females) pushed a cart with an unknown weight at one push every two minute for a distance of 3.9 m. Two independent variables were investigated, cart...
از دیدگاه اقتصادی، شناسایی و کمی سازی عدم قطعیت عیاری دارای اهمیت بالایی در رده بندی منابع می باشد. برای کمی سازی عدم قطعیت می توان از تکنیک های شبیه سازی شرطی که کاربرد فراوانی نیز در منحنی های تناژ- عیار و رده بندی منابع دارند، استفاده نمود. این روش ها، برای کانسارهای تک عنصره قابل کاربرد می باشند، اما در کانسارهای چند عنصره که در آن ها لحاظ نمودن همبستگی فضایی از اهمیت بسزایی برخوردار است، ب...
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