Oncostatin M has been characterized as a potent growth inhibitor for various tumor cells. Oncostatin M-treated glioblastoma cells cease proliferation and instigate astrocytal differentiation. The oncostatin M-induced cell cycle arrest in G(1) phase is characterized by increased level of the cyclin-dependent kinase (CDK) inhibitory proteins p21(Cip1/Waf1/Sdi1) and p27(Kip1). Induction of p21 pro...

background and objective: organisms producing ctx-m β-lactamases are emerging as a source of resistance to oxyiminocefalosporins such as ceftriaxone and ceftazidime. however, the laboratory detection of these strains is not well defined. in this study, phenotypic assay for screening of extended-spectrum β-lactamases producing strains and molecular assay for the identification of ctx-m β-lactama...

Objective(s): To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). Materials and Methods: Two-cell mouse embryos were cultured in 3 groups: simple media, melatonin-treated (10-9 M melatonin) and Luzindole-treated (10-9 M luzindole). Then, the rate of ErbB1 and ErbB4 gene and protein expression, the leve...

In many parts of Iran high light intensities during summer can induce stress in cut flower production under open field and greenhouse conditions. Despite roses prefer sunny places for optimum growth, but in practice some levels of rough shading is applied in greenhouse production to improve the quality of cut flowers. So, it is useful to find the light intensities under which different rose cul...

Background and Aims: Newcastle disease virus (NDV) is an avian paramyxovirus (A-PMV 1) and one of the major pathogens in poultries. Vaccination is intended to control the disease, nevertheless this virus is a growing threat to the poultry industry. So, early detection of the virus can prevent the spread of illness and avoid huge economic losses. Towards this goal, in this research, we develop...

A completely randomized design, with 3×3 factorial arrangement, was conducted to test various ratios of dietary protein to energy (P/E) for rainbow trout, reared in brackish water. Three crude protein levels (35, 40 and 45%) and three energy levels (370, 400 and 430 Kcal/100g) at each protein level were utilized. Semi-purified diet containing fish meal, casein and gelatin as the sources o...

Objective(s): Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins for the purpose of diagnosing M. tuberculosis infection or for the immuniza...

cirrhosis is the consequence of chronic liver disease. deleterious effects of oxidative stress on hepatocytes may be reflected in the erythrocyte membrane. naltrexone (ntx) has been shown to attenuate hepatocellular injury in fibrotic animal models. the aim of this study was to investigate the progressive effect of ccl 4 on the liver and whether the improvement of liver cirrhosis can be monitor...