Andrographolide is one of the principal components of a famous traditional Chinese herbal medicine, Andrographis paniculate (Burm) Nees, and has been widely used in the clinic for the treatment of infectious diseases. In this paper, metabolites of andrographolide in the urine of eight healthy volunteers after oral administration were further investigated. Building on previous findings, an addit...

let $p$ be a prime number greater than three. in this paper, we prove the existence of a new family of homotopy elements in the stable homotopy groups of spheres $pi_{ast}(s)$ which is represented by $h_nh_mtilde{beta}_{s+2}in {rm ext}_a^{s+4, q[p^n+p^m+(s+2)p+(s+1)]+s}(mathbb{z}_p,mathbb{z}_p)$ up to nonzero scalar in the adams spectral sequence, where $ngeq m+2>5$, $0leq sext}_a^{s+2,q[(s+2)p...

We have studied the correlations among three absolute neutrino mass observables---the effective Majorana (${m}_{ee}$) which can be obtained from neutrinoless double beta decay, electron (${m}_{\ensuremath{\beta}}$) is measured in single decay experiments, and sum of light masses ($\mathrm{\ensuremath{\Sigma}}$) constrained cosmological observations, context minimal left-right symmetric model. T...

In this work we consider the fractional Kirchhoff equations with singular nonlinearity, $$\displaylines{ M\Big( \int_{\mathbb{R}^{2N}}\frac{|u(x)-u(y)|^p}{|x-y|^{N+sp}}dx dy\Big) (-\Delta)^s_p u = \lambda a(x)|u|^{q-2}u +\frac{1-\alpha}{2-\alpha-\beta} c(x)|u|^{-\alpha}|v|^{1-\beta}, \quad \text{in }\Omega,\cr \int_{\mathbb{R}^{2N}}\frac{|v(x)-v(y)|^p}{|x-y|^{N+sp}}dx v \mu b(x)|v|^{q-2}v +\fra...

MHC class I molecules and beta(2)-microglobulin (beta(2)m) are membrane glycoproteins that present peptide Ags to TCRs, and bind to inhibitory and activating receptors on NK cells and other leukocytes. They are involved in the discrimination of self from non-self. Modification of these molecules in the placenta benefits pregnancy, but little is known about their genes in the uterus. We examined...

The presence and location of receptors for aggregated human beta 2-microglobulin (beta 2m) on the surface of group A, C, and G streptococci were studied by electron microscopic techniques. Ferritin-conjugated aggregates of human beta 2m were used in direct binding experiments. Ferritin-conjugated antibodies against beta 2m were employed in a two-step indirect binding assay where the streptococc...

Imbalances of beta-adrenoceptor (beta-AR) and muscarinic ACh receptor (mAChR) input are thought to underlie perinatal cardiovascular abnormalities in conditions such as sudden infant death syndrome. Administration of isoproterenol, a beta(1)/beta(2)-AR agonist, to neonatal rats on postnatal days (PN) 2-5 caused downregulation of cardiac m(2)AChRs and a corresponding decrement in their control o...

BACKGROUND The clinicoepidemiologic relevance of moderately elevated concentrations of circulating beta(2)-microglobulin (beta(2)-M) has not been established. METHODS We examined whether serum beta(2)-M concentration independently predicts total mortality in community-dwelling older populations and compared its predictive value with that of cystatin C and C-reactive protein (CRP) using a pros...