نتایج جستجو برای: lyp
تعداد نتایج: 229 فیلتر نتایج به سال:
مقدمه: سقط مکرر به ختم بارداری بیش از دو بار اطلاق می‌شود. عوامل متعددی در ایجاد سقط مکرر دخیل هستند، وجود اختلال در عملکرد سیستم ایمنی منجر به دفع جنین می‌شود. آنزیم پروتئین تیروزین فسفاتاز بافت لنفاوی (Lyp) که توسط ژن PTPN22 کد می‌شود، نقش حیاتی در تنظیم و تعادل پاسخ‌های ایمنی دارد؛ به‌تازگی پلی‌مورفیسم rs2488457که در ناحیه پروموتر این ژن قراردارد کشف شده است، محتمل است این پلی‌مورفیسم با تغ...
Observation: The CD30 antigen is a type-1 transmembrane glycoprotein which is a member of the tumor necrosis factor receptor family and may be expressed on activated B and T cells. CD30+ lymphoproliferative disorders (CD30+ LPDs) mainly include primary cutaneous CD30+ anaplastic large-cell lymphoma (pcALCL) and lymphomatoid papulosis (LyP). Other CD30 +LPD showing skin lesions are large cell tr...
RNA interference has been used to dissect the importance of individual gene products in various human disease processes, including cancer. Small-interfering RNA, or siRNA, is one of the tools utilized in this regard, but specially-designed delivery agents are required to allow the siRNA to gain optimal access to the cell interior. Our laboratory has utilized two different siRNA-binding delivery...
The performance of a variety of high-level composite procedures, as well as lower-cost density functional theory (DFT)- and second-order perturbation theory (MP2)-based methods, for the prediction of absolute and relative R-X bond dissociation energies (BDEs) was examined for R = Me, Et, i-Pr and t-Bu, and X = H, CH(3), OCH(3), OH and F. The methods considered include the high-level G3(MP2)-RAD...
Environmental changes associated with modern lifestyles may underlie the rising incidence of Type 1 diabetes (T1D). Our previous studies of T1D families and the BioBreeding (BB) rat model have identified a peripheral inflammatory state that is associated with diabetes susceptibility, consistent with pattern recognition receptor ligation, but is independent of disease progression. Here, compared...
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