Peripheral blood lymphocyte subpopulations of 47 patients with bladder cancer were analyzed using monoclonal antibodies (OKT3, OKT4, OKT8 and OKIa7). Thirty five patients were untreated, and 12 were treated, disease-free patients. In untreated patients, the number of total lymphocytes and the percentage of OKT3+ cells decreased. Among the OKT3+ T cell population, the percentage of OKT4+ cells t...

T-lymphocyte populations in 12 apparently healthy heterosexual adult patients with hemophilia have been examined to ascertain if these patients have abnormalities in their lymphocyte subpopulations similar to those in homosexual men, Haitian refugees, and narcotic addicts. A striking reduction in the helper to suppressor cell ratio ([0.86 +/- 0.14]:1) was found in 9 of the 12 patients. These ab...

Alterations in blood lymphocyte subsets may be involved in the development of overt myeloma. Naive (CD4+CD45RA+) and memory (CD4+CD45RO+) helper T-cell subsets are important effectors of immune T-cell regulation. We analyzed the distribution of these blood lymphocyte subpopulations in patients with monoclonal gammopathies, considering the type of disorder, clinical stage, and treatment status.

Preincubation of human blood lymphocytes with cell surface antigen specific antibodies under non-capping conditions reduces the electrophoretic mobility of the corresponding lymphocyte subpopulation. Antigen-positive and antigen-negative cells can be separated by free flow electrophoresis with high yield, purity and viability. The use of fluorescence-labelled second antibodies augments the indu...

communications to the editor Communications for this section will be published as space and priorities permit. The comments should not exceed 350 words in length, with a maximum offive references; onefigure or table can be printed. Exceptions may occur under particular circumstance& Contributions may include comments on articles publ&,ed in thts periodical, or they may be reports ofunique educa...