Background. Differentiating Systemic lupus erythematosus (SLE) from other autoimmune rheumatic diseases and undifferentiated connective tissue diseases may be difficult. Diagnosing SLE early and more accurately is important for patient education and for the institution of appropriate treatment to reduce morbidity. The aim of this study is to investigate the prevalence and diagnostic significanc...

Objective: Laboratory and histological evaluation of patients with lupus glomerulonephritis treated at Hospital Getúlio Vargas, in Teresina, Piauí. Methods: Descriptive, retrospective study, whose data were collected by consulting electronic medical records forms. Results: 33 evaluated, a mean age 30.45±10.19 years, female prevalence (96.97%). Most had altered creatinine values ​​(51.51%) 24-ho...

MRL/MpJ-Tnfrsf6(lpr) (MRL/MpJ-Fas(lpr); MRL-Fas(lpr)) mice develop a spontaneous lupus syndrome closely resembling human systemic lupus erythematosus. To define the role of IL-10 in the regulation of murine lupus, IL-10 gene-deficient (IL-10(-/-)) MRL-Fas(lpr) (MRL-Fas(lpr) IL-10(-/-)) mice were generated and their disease phenotype was compared with littermates with one or two copies of an int...

Immune mediated nephropathy is one of the most serious manifestations of lupus and is characterized by severe inflammation and necrosis that, if untreated, eventually leads to renal failure. Although lupus has a higher incidence in women, both sexes can develop lupus glomerulonephritis; nephritis in men develops earlier and is more severe than in women. It is therefore important to understand t...

In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss 2012 KDIGO glomerulonephritis guideline context new developments and insights that had occurred over years since its publication. During this Controversies Conference on Glomerular Diseases, group examined data disease pathogenesis, bio...