Introduction: Planning target volume (PTV) is generated from internal treatment volume (ITV) using four-dimensional computed tomography (4D-CT) for enhanced therapeutic gain in the stereotactic body radiotherapy for lung lesions (SBRT-Lung). This study aimed to propose a strategy to generate ITV on multiple-phase 3D-CT and enhance therapeutic gain in SBRT-Lung. <stron...

The segmentation, detection and extraction of the infected tumor from Magnetic Resonance Imaging (MRI) images are key concerns for radiologists or clinical experts. But it is tedious time consuming its accuracy depends on their experience only. This paper suggest a new methodology recognition, classification different types cancer cells both MRI RGB (Red, Green, Blue) performed using supervised...

Abstract Aims: To investigate the effect of Myrtenol, the active ingredient of Myrtle, on the oxidant and anti-oxidant indices and cytokines in the allergic asthma. Methods: Allergic asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats; Control, Asthma, Asthma+Dexamethasone and Asthma+Myrtenol. Myrtenol (50mg/kg) or Dexamethasone (2.5mg/kg) was a...

BACKGROUND The rabbit VX2 lung cancer model is a large animal model useful for preclinical lung cancer imaging and interventional studies. However, previously reported models had issues in terms of invasiveness of tumor inoculation, control of tumor aggressiveness and incidence of complications. PURPOSE We aimed to develop a minimally invasive rabbit VX2 lung cancer model suitable for imaging...

Background: Boron neutron capture therapy (BNCT) is a radiotherapy that combines biological targeting and high linear energy transfer. A potential therapeutic approach for non-small cell lung cancer (NSCLC) is considered. However, dose in lung tumor is not homogeneous, and it will reduce the effect of BNCT treatment. In order to improve the dose distribution of BNCT, the multi-field irradiation...

NOTCH signaling is an evolutionarily conserved signaling pathway that regulates cell fate during development and postnatal life. It has been increasingly linked to carcinogenesis, although its role in cancer seems to be highly context and tissue specific. Although NOTCH signaling is required for lung development, little is known about its role in lung cancer. In this study, we show that NOTCH s...

background: breast cancer (bc) is the second most commonly diagnosed cancer after lung cancer. survival of bc patients is affected by intermediate events. this study was aimed to investigate the disease course of primary non-metastatic bc patients with first recurrence of the tumor (frt) as the intermediate event using the illness- death model. methods: this retrospective cohort study was condu...

breast cancer is the most common cause of cancer-related death in female, after lung cancer. angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. the role of vascular endothelial growth factor that assumed to be most potent angiogenesis factor is ambiguous in breast cancer. this study descri...

Background: Radiation‐induced acute lung damages are refractory side effects in lung cancer radiotherapy (RT). Prospective study investigates the possible role of piperine (Pip) as anti-inflammatory agent against &gamma;-rays-induced lung tissue lesions in an applicable rat model. Materials and Methods: Fifty-six Sprague-Dawley rats were divided into four groups: Control, rats were administered...

Beta1 integrins, expressed on the cell surface of human non-small cell lung carcinomas, are used here as a target for the selective delivery of anti-cancer drug-loaded liposomes. Fab' fragments of a monoclonal antibody specific for human beta1 integrins were conjugated to sterically stabilized liposomes. Confocal microscopy of beta1 integrin-positive lung tumor cells incubated with fluorescentl...