نتایج جستجو برای: lung delivery

تعداد نتایج: 508290  

Journal: :Anesthesiology 2011
John F Bebawy

Introduction Diagnosis (Clinical Approaches) Cigarette Smoking and Molecular Epidemiology of Lung Cancer Molecular Abnormalities in Lung Cancer: A Disease of the Cell Cycle Role of p53 as the Guardian of the Genome and Protector of the Lung from Environmental Carcinogens The p16 Tumor Suppressor Pathway Transforming Growth Factorb Induces p15 Role of Activated Oncogenic ras in the Genesis of Lu...

2010
Chuxiong Ding Cheng‐Hui Chang Joshua Haslam Robert Timmerman Timothy Solberg

The aim of this study is to compare the dosimetric characteristics of robotic and conventional linac-based SBRT techniques for lung cancer, and to provide planning guidance for each modality. Eight patients who received linac-based SBRT were retrospectively included in this study. A dose of 60 Gy given in three fractions was prescribed to each target. The Synchrony Respiratory Tracking System a...

2013
Ronak Savla Tamara Minko

Cystic fibrosis (CF) is an autosomal recessive monogenetic disease that afflicts nearly 70,000 patients worldwide. The mutation results in the accumulation of viscous mucus in multiple organs especially in the lungs, liver and pancreas. High associated morbidity and mortality is caused by CF due to the lack of effective therapies. It is widely accepted that morbidity and mortality caused by CF ...

2012
Paul Zarogoulidis Ekaterini Chatzaki Konstantinos Porpodis Kalliopi Domvri Wolfgang Hohenforst-Schmidt Eugene P Goldberg Nikos Karamanos Konstantinos Zarogoulidis

Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy an...

Journal: :Journal of applied physiology 1999
W D Bennett G Scheuch K L Zeman J S Brown C Kim J Heyder W Stahlhofen

The regional deposition of particles in boluses delivered to shallow lung depths and their subsequent retention in the airways may depend on the lung volume at which the boluses are delivered. To evaluate the effect of end-inspiratory lung volume on aerosol bolus delivery, we had healthy subjects inhale radiolabeled, monodisperse aerosol (99mTc-iron oxide, 3.5-microm mass median aerodynamic dia...

Journal: :International journal of molecular medicine 2014
Yiqun Han Peng Zhang Yuanyuan Chen Jiping Sun Fansheng Kong

The co-delivery of DNA and antitumor drugs has the potential to treat cancer. In this study, we aimed to develop surface-modified, co-encapsulated solid lipid nanoparticles (SLN) containing enhanced green fluorescence protein plasmid (pEGFP) and doxorubicin (DOX) in order to create a multifunctional delivery system that targets lung cancer cells, in an effort to improve the efficacy of cancer t...

Journal: :Journal of immunology 2011
Kathrin Steinwede Ole Tempelhof Kristine Bolte Regina Maus Jennifer Bohling Bianca Ueberberg Florian Länger John W Christman James C Paton Kjetil Ask Shyam Maharaj Martin Kolb Jack Gauldie Tobias Welte Ulrich A Maus

The growth factor GM-CSF has an important role in pulmonary surfactant metabolism and the regulation of antibacterial activities of lung sentinel cells. However, the potential of intra-alveolar GM-CSF to augment lung protective immunity against inhaled bacterial pathogens has not been defined in preclinical infection models. We hypothesized that transient overexpression of GM-CSF in the lungs o...

Journal: :Journal of applied physiology 1997
D P Carlton K H Albertine S C Cho M Lont R D Bland

To investigate the role of neutrophils in the pathogenesis of respiratory distress after premature birth, we assessed the relationship between circulating neutrophil concentration and neutrophil accumulation in the lung, lung lymph and pleural liquid flow, and extravascular lung water in 10 chronically catheterized preterm lambs (127 +/- 1 days gestation) that were mechanically ventilated for 8...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Machiko Ikegami Suhas G Kallapur Alan H Jobe

Preterm delivery is frequently preceded by chorioamnionitis, resulting in exposure of the fetal lung to inflammation. We hypothesized that ventilation of the antenatally inflamed lung would result in amplification of the lung injury. Therefore, we induced fetal lung inflammation with intra-amniotic endotoxin (10 mg of Escherichia coli 055:B5) 4 days before premature delivery at 130 days of gest...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001
S R Thomas

UNLABELLED There has been no consensus on a standard calculational approach regarding the concept of administered activity in ventilation studies involving inhaled radioisotope gas or radioaerosols. This is caused in part by a lack of knowledge regarding the actual activity that enters the lung space (as opposed to activity introduced into the delivery system) and to the extended administration...

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