Background Cytotoxic mechanisms are involved in most forms of drug-induced skin diseases, but till now only a small number of studies has been addressed the question whether in vitro detection of cytotoxic drug-specific response could be helpful in drug hypersensitivity diagnosis. The aim of this study was to assess and compare different cytotoxic tests as an alternative nonradioactive approach...

Centro de Quı́mica Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal, Universidade Aberta, R. da Escola Politécnica, 147, 1269-001 Lisbon, Portugal, Lehrstuhl für Technische Thermodynamik (LTT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Am Weichselgarten 8, D-91058 Erlangen, Germany, School of Physical, Environmental and ...

Introduction: Proper packing technique is crucial to minimize blood loss and successfully stop fatal junctional (axilla, groin, neck) bleedings. Several medical simulators mannequins are used teach techniques for manual pressure wound packing. Live tissue training (LTT) using animal models represents a high-fidelity simulator, but the number of times massive hemorrhage can be practiced limited ...

The deployment of new 5G services and future demands for 6G make it necessary to increase the performance access networks. This challenge has prompted development standardization proposals Passive Optical Networks (PONs) that offer greater bandwidth, reach a higher rate aggregation users per fiber, being Time- Wavelength-Division Multiplexing (TWDM) promising technological solution increasing c...

BACKGROUND Specific immunotherapy (SIT) is believed to modulate CD4+ T-helper cells. In order to improve safety, SIT vaccines are often formulated with allergoids (chemically modified allergens). Interaction between T-cells and allergoids is necessary to influence cellular cytokine expression. There have been few reports on identification the early cellular effects of SIT. METHOD Patients all...