PURPOSE In diabetes, an impaired antioxidant defense system contributes to the development of diabetic retinopathy. The main objective of this paper was to find correlations of oxidative stress parameters within and between the vitreous and serum in patients with type 2 diabetes who had developed proliferative diabetic retinopathy. METHODS The study included and compared two groups of patient...

In vitro treatment of erythrocytes of normal and hypercholesterolemic rats with N-nitrosodiethylamine (NDEA), an important carcinogen frequently present in human environment and food chain resulted in a marginal increase in osmotic fragility of erythrocytes without affecting their antioxygenic potential as evidenced by insignificant effect on lipid peroxidation (LPO). However, (LPO) of all the ...

Effect of Garlic against mercuric chloride induced toxicity in albino rats was studied. Oral administration of mercuric chloride (100mg/kg/p.o) for 30 days resulted in significant increase in LPO Basal level and LPO FeSO(4) induced and significant decrease in GSH (Glutathione) and Vit C as compared to the normal and control group. Simultaneous administration of Garlic along with Mercuric chlori...

The present study was designed with an objective to assess the inhibition of lipid peroxidation (LPO) by the aqueous extract of Calocybe indica (milky mushroom) using an invitro model of goat liver homogenate and RBC ghosts. The invitro LPO was inhibited to a good extent by the aqueous extract of milky mushroom and the extent of inhibition being higher in the RBC membrane model when compared wi...

Chronic toxicity of copper (Cu) at sublethal levels is associated with ionoregulatory disturbance and oxidative stress. These factors were considered in a toxicokinetic-toxicodynamic model the present study. The was evaluated by activity Na+/K+-ATPase enzyme (NKA), while stress presented lipid peroxidation (LPO) glutathione-S-transferase (GST) activity. NKA related to binding Cu2+ Na + NKA. LPO...

Tryptoline and pinoline are two â-carbolines isolated from the nervous system of mammals. We have investigated the level of lipid peroxidation (LPO) in rat brain homogenates in the presence of nitric oxide (NO) which was released by the addition of sodium nitroprusside ( SNP ).We also examined the effect of other known antioxidants (vitamin E) on the NO-induced LPO. The concentration of malonal...

The aim of the study was to elucidate the state of lipid metabolism, the processes of lipid peroxidation (LPO) and the state of the antioxidant system (AOS) in pregnant women with metabolic syndrome. A comprehensive examination of pregnant women without pathology was performed, with signs of a metabolic syndrome. Analysis of the data showed that in pregnant women with impaired glucose metabolis...

Nutmeg, the dried seed kernel of Myristica fragrans, MF (Family: Myristicaceae) possesses antifungal, hepatoprotective and antioxidant properties. Its radioprotective effect against 6, 8 and 10 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD(50/30 )as 6.83 Gy and 8.89 Gy for irradiated only and (MF + radiation) groups, respectively. The dose reduction f...

In stress conditions, the formation of ROS by mitochondria increases, which leads to a shift in the antioxidant prooxidant balance toward increasing the ROS content in the cell. The interaction of ROS with polyunsaturated fatty acids, which enter into the composition of the lipids of mitochondrial membranes, leads to the activation of lipid peroxidation (LPO). Herewith in 2.5 3 times increased ...