In vivo imaging enables us to peer deeply within living subjects and is producing tremendous opportunities both for the study of cancer biology and clinical diagnostics. Rapid advances in fluorescent imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasound imaging promise to translate the insights from basic science at the single-ce...

The objective of this work was the synthesis of serum albumin targeted, Gd(III)-based magnetic resonance imaging (MRI) contrast agents exhibiting a strong pH-dependent relaxivity. Two new complexes (Gd-glu and Gd-bbu) were synthesized based on the DO3A macrocycle modified with three carboxyalkyl substituents α to the three ring nitrogen atoms, and a biphenylsulfonamide arm. The sulfonamide nitr...

Integration of optical and magnetic resonance imaging (MRI) methods in one setting is appealing due to the complementary nature of MRI’s high spatial and temporal resolution and the high molecular sensitivity of optical imaging. In particular, deep tissue penetration of near-infrared (NIR) photons and minimal autofluorescence in this wavelength range favors the assessment of molecular events in...

Ferritin has gained significant attention as a potential reporter gene for in vivo imaging by magnetic resonance imaging (MRI). However, due to the ferritin ferrihydrite core, the relaxivity and sensitivity for detection of native ferritin is relatively low. We report here on a novel chimeric magneto-ferritin reporter gene - ferritin-M6A - in which the magnetite binding peptide from the magneto...

UNLABELLED Polyethylene glycol (PEG) surface modification can make nanomaterials highly hydrophilic, reducing their sequestration in the reticuloendothelial system. In this study, polyamidoamine (PAMAM) dendrimers bearing gadolinium (Gd) chelates were PEGylated with different PEG-chain lengths, and the effects on paramagnetic and pharmacokinetic properties were evaluated. Specifically, Gd chela...

With the applications of magnetic resonance imaging (MRI) at higher magnetic fields increasing, there is demand for MRI contrast agents with improved relaxivity at higher magnetic fields. Macromolecule-based contrast agents, such as protein-based ones, are known to yield significantly higher r1 relaxivity at low fields, but tend to lose this merit when used as T1 contrast agents (r1/r2 = 0.5 ~ ...

INTRODUCTION MR cellular imaging using iron-oxide-based contrast agents is an attractive technique in cell tracking and monitoring cell therapies. However, one major obstacle of the widespread application of this technique in clinics is the low sensitivity inherently associated with MRI. Therefore, there are a lot of efforts aimed at enhancing the susceptibility effect induced by the iron-oxide...

Abstract Early diagnosis of cancer has become one the effective ways to prevent and treat cancer. At present, magnetic resonance imaging (MRI) based on nanosized iron oxide with no toxicity excellent biocompatibility attracted much attention. But poor stability fluid (MF) is becoming more prominent. In view MF, dodecanethiol-poly(methacrylic acid) (DDT-PMAA) as an outer shell was prepared for M...