BACKGROUND Among schizophrenia patients relapsed on an oral antipsychotic (AP), this study compared the impact of switching to atypical AP long-acting injectable therapy (LAT) versus continuing oral APs on hospitalization and emergency room (ER) visit recurrence. METHODS Electronic records from the Premier Hospital Database (2006-2010) were analyzed. Adult patients receiving oral APs during a...

This paper details a method of estimating the uncertainty of dimensional measurement for a three dimensional coordinate measurement machine. An experimental procedure was developed to compare three dimensional coordinate measurements with calibrated reference points. The reference standard used to calibrate these reference points was a fringe counting interferometer with a multilateration like ...

AIM Anoestrus is one of the most common functional disorders of the reproductive cycle in buffaloes. In spite of technical advancement, there is no single cure for the management of anoestrus. Therefore, the aim of this study was to find out the efficacy of gonadotropic releasing hormone (GnRH) and metabolic hormone for the management of true anoestrus in buffaloes. MATERIALS AND METHODS The ...

OBJECTIVE To review insulin detemir for clinical use to better manage patients with type 1 and type 2 diabetes. METHODS A MEDLINE search, in English, from June 30, 2006 to December 1, 2008, using the terms "insulin analogs," "insulin detemir" and "long-acting insulin analog." RESULTS Insulin detemir improves glycemic control, based on HbA(1C) reduction and fasting glucose levels, without in...

We experimentally demonstrate the technique of light-assisted, templated self-assembly (LATS) to trap and assemble 200 nm diameter gold nanoparticles. We excite a guided-resonance mode of a photonic-crystal slab with 1.55 μm laser light to create an array of optical traps. Unlike our previous demonstration of LATS with polystyrene particles, we find that the interparticle interactions play a si...

The 15 years since 1950 have seen the discovery of aldosterone, calcitonin, and a long-acting thyroid stimulator, and the development of sensitive and specific assay methods for many of the hormones in plasma. Our understanding of many endocrine diseases has greatly increased, even though treatment has not changed dramatically. In this article I propose to deal with some of the more important o...

Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine (1) are superior to those of insulin NPH (2–9). In the clinical setting, this translates into lower risk of nocturnal hypoglycemia (10–13), lower A1C (provided that appropriate requirements of mealtime rapid-acting insulin are met) (11–13), and the convenience of once (12), compared with multiple, administration of...

      Background: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of lo...

Exenatide has been widely used for the treatment of type 2 diabetes mellitus. However, its short plasma half-life of 2.4 hours has limited its clinical application. The exenatide products on the market, twice-daily Byetta™ and once-weekly Bydureon™ (both Amylin Pharmaceuticals, San Diego, CA, USA), are still not perfect. Many researchers have attempted to prolong the acting time of exenatide by...

UNLABELLED Aims/Introduction:  Although long-acting insulin analogs are recommended in type 2 diabetics failing on oral agents, their efficacy is uncertain. Here we compared the efficacy and safety of regimens based on long-acting insulin analogs with other preparations in insulin-naïve type 2 diabetics failing on oral agents. MATERIALS AND METHODS   Data from 9548 participants in 22 English ...