Local hematopoietic bone marrow (BM) renin-angiotensin system (RAS) affects the growth, production, proliferation differentiation, and function of hematopoietic cells. Angiotensin II (Ang II), the dominant effector peptide of the RAS, regulates cellular growth in a wide variety of tissues in pathobiological states. RAS, especially Ang II and Ang II type 1 receptor (AT1R), has considerable proin...

colorectal cancer (crc) is one of the most common cancers worldwide. understanding of the tumor behavior, in a much closer look, at the molecular level, results in a more effective treatment and accurate prognosis of the disease. from among various genes altered in colorectal cancer k-ras is assumed to be of diagnostic and prognostic significance. k-ras mutations are believed to be a critical e...

Abstract This article studies the transmission of Global Financial Cycle (GFC) to domestic credit market conditions in a large emerging market, Turkey, over 2003–13. We use administrative data covering universe corporate transactions matched bank balance sheets document four facts: (1) an easing global financial leads lower borrowing costs and increase local lending; (2) banks more exposed inte...

Context: This study investigated the uses of statistical techniques in nursing research articles (RAs) published within 2016 - 2020. Evidence Acquisition: Through stratified random sampling, 374 quantitative and mixed-method RAs were selected from five journals (i.e., International Journal Nursing Studies, Scholarship, Nurse Education Today, Outlook, Cardiovascular Nursing) The used these deriv...

Although the renin-angiotensin system (RAS) was classically considered as a circulating system that regulates blood pressure, many tissues are now known to have a local RAS. Angiotensin, via type 1 receptors, is a major activator of the NADPH-oxidase complex, which mediates several key events in oxidative stress (OS) and inflammatory processes involved in the pathogenesis of major aging-related...

The activity of a local renin-angiotensin system (RAS) in the adipose tissue is closely associated with obesity-related diseases. However, the mechanism of RAS activation in adipose tissue is still unknown. In the current study, we found that palmitic acid (PA), one kind of free fatty acid, induced the activity of RAS in 3T3-L1 adipocytes. In the presence of fetuin A (Fet A), PA upregulated the...

abstract :  reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  the efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  cells expressing activated ras and t...