The aim of this study was to identify long non-coding RNA (lncRNA) associated with osteogenic differentiation from mesenchymal stem cells (MSCs) using high-throughput RNA sequencing (RNA-Seq) data. RNA-Seq dataset was obtained from the European Bioinformatics Institute (accession No. PRJEB4496), including two replicates each for immortalized mesenchymal stem cells iMSC#3 cultured in growth medi...

Transcription activator-like effector nucleases (TALENs) have so far been applied to disrupt protein-coding genes which constitute only 2-3% of the genome in animals. The majority (70-90%) of the animal genome is actually transcribed as non-coding RNAs (ncRNAs), yet the lack of efficient tools to knockout ncRNA genes hinders studies on their in vivo functions. Here we have developed novel strat...

تعمج تانايبلا . ةيجهنم ةعجارم تناك ةساردلا هذه :هقیرطلا و ةصالخا تاملكلا لامعتساو تانايبلا ةدعاق يف ثحبلا للاخ نم زجالحا " :یتلاا تناك ةصالخا تاملكلا .ثحبلا یف قمعتلا ريياعلما . " ةطبثلما لماوعلا " و "ءاسنلل ةدلاولا لبق ةياعرلا " لوصو" ٬" یف قمعتلا وةساردلا دعب .OR ،AND تناك ةيقطنلما لماوعلا تلااقم تددحو تضفر ةطبارتم ريغ تلااقم ، هفلتخلما تلااقلما تلااقلما رايتخلاا رايعم .تلااقلما لذل اصخلم اها...

Non‑coding RNAs serve important roles in regulating the expression of certain genes and are involved in the principal biological processes of breast cancer. The majority of studies have focused on defining the regulatory functions of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs), and few studies have investigated how lncRNAs and miRNAs are transcriptionally regulated. In the presen...

ةــصلاـخلا : سا وه ةنيجهلا ملعتلا ةمظنأ يدحت نإ تامولعملا رداصم دحأ نم ةعبانلا تامولعملا لامعت رخآ ردصم نع ةمجانلا صئاقنلا ةنزاومل . كلذ و ةدعاو ثحب ةهجو لثمي يزمرلا يكبشلا جزملا نإ ةيزمرلا نيتقيرطلا نيب دضاعتلا نلأ ) ةيرظنلا ( ةيكبشلا و ) ةيبيرجتلا ( لآ لامعتسا نم ةيلاعف رثآأ ادح ىلع امهنم ةدحاو . لا اذه فصي ،يزمر يكبش فنصم ةطساوب ةيفرحلا ةيبرعلا غلابملا ىلع فرعتلل اماظن ثحب ،ةيلاملا غلابملا...

ناآ دقل رهوج ،ةيفخ ةفصب تامولعملا لاسرإ و لاصتلاا عوضوم مدقلا ذنم مامتهلاا و ديعب نمز ذنم عساو لكشب مدختست ةيصنلا قئاثولا تناآ ، صوصنلا يف تامولعملا ءافخلإ ةفلتخم اًقرط مويلا ىتح نمز ذنم دهشن نحن كلذل ) Text Steganography .( لاقملا اذه نإ ط لوانتي ةيبرعلا و ةيسرافلا صوصنلا يف تامولعملا ءافخلإ ةديدج ةقير . و دوآ ينويلا ةفصاوم يف دجوي ) Unicode ( ءايلا فرحل نافلتخم نازمر » ى « ، فاكلا فرحل كلذآو...

Accumulating evidence indicates that long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) involve in germ cell development. However, little is known about the functions and mechanisms of lncRNAs and circRNAs in self-renewal and differentiation of germline stem cells. Therefore, we explored the expression profiles of mRNAs, lncRNAs, and circRNAs in male and female mouse germline stem cells...

Exosomes are 30-150nM membrane-bound secreted vesicles that are readily isolated from biological fluids such as urine (UEs). Exosomes contain proteins, micro RNA (miRNA), messenger RNA (mRNA), and long non-coding RNA (lncRNA) from their cells of origin. Although miRNA, protein and lncRNA have been isolated from serum as potential biomarkers for benign and malignant disease, it is unknown if lnc...