نتایج جستجو برای: lncrna

تعداد نتایج: 6925  

Journal: :International journal of clinical and experimental pathology 2015
Ying-Kun Ren Yan Xiao Xiang-Bin Wan Yu-Zhou Zhao Jian Li Yin Li Guang-Sen Han Xiao-Bing Chen Qi-Yun Zou Gang-Cheng Wang Chao-Min Lu Yong-Chao Xu You-Cai Wang

Long non-coding RNA (lncRNA) has an important role in carcinoma progression and prognosis. However, little is known about the pathological role of lncRNA HOTTIP (HOXA transcript at the distal tip) in colorectal cancer (CRC) patients. This study attempted to investigate the association of lncRNA HOTTIP expression with progression and prognosis in CRC patients. LncRNA HOTTIP expression was measur...

2016
Ping Li Guojun Zhang Juan Li Rui Yang Shanshan Chen Shujun Wu Furui Zhang Yong Bai Huasi Zhao Yuanyuan Wang Shaozhi Dun Xiaonan Chen Qianqian Sun Guoqiang Zhao

Lung cancer is the most common cause of cancer-related mortality worldwide. It is a complex disease involving multiple genetic and epigenetic alterations. The development of transcriptomics revealed the important role of long non-coding RNAs (lncRNAs) in lung cancer occurrence and development. Here, microarray analysis of lung adenocarcinoma tissues showed the abnormal expression of lncRNA RGMB...

2016
Ling Feng Ru Wang Meng Lian Hongzhi Ma Ning He Honggang Liu Haizhou Wang Jugao Fang

Long non-coding RNA (lncRNA) plays an important role in tumorigenesis. However, the expression pattern and function of lncRNAs in laryngeal squamous cell carcinoma (LSCC) are still unclear. To investigate the aberrantly expressed lncRNAs and mRNAs in advanced LSCC, we screened lncRNA and mRNA expression profiles in 9 pairs of primary Stage IVA LSCC tissues and adjacent non-neoplastic tissues by...

Journal: :Arthritis & rheumatology 2014
Qiang Liu Xin Zhang Linghui Dai Xiaoqing Hu Jingxian Zhu La Li Chunyan Zhou Yingfang Ao

OBJECTIVE Long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biologic processes, but knowledge of lncRNAs in osteoarthritis (OA) is limited. The aim of this study was to identify lncRNA expression in articular cartilage and to explore the function of cartilage injury-related lncRNAs (lncRNA-CIR) in OA. METHODS To identify lncRNAs specifically expressed in OA cartilage, we ...

2017
Zhao Wang Qun Wang Jiachen Wang Yaqing Si Jiaxiang Yuan Jiaxiang Wang

The expression pattern of long non-coding RNA (lncRNA) has been reported to be a new player in various diseases, including cancer. Aberrant expression of these genes will affect tumorigenesis through either oncogenic or tumor suppressive pathways. Hepatocellular carcinoma (HCC), with the increasing incidence, has become the second deadly cancer in men and the sixth in women in the world. Given ...

2015
Xing Chen Chenggang Clarence Yan Cai Luo Wen Ji Yongdong Zhang Qionghai Dai

Increasing evidence has indicated that plenty of lncRNAs play important roles in many critical biological processes. Developing powerful computational models to construct lncRNA functional similarity network based on heterogeneous biological datasets is one of the most important and popular topics in the fields of both lncRNAs and complex diseases. Functional similarity network construction cou...

2016
Liang Cheng Hongbo Shi Zhenzhen Wang Yang Hu Haixiu Yang Chen Zhou Jie Sun Meng Zhou

Increasing evidence indicated that long non-coding RNAs (lncRNAs) were involved in various biological processes and complex diseases by communicating with mRNAs/miRNAs each other. Exploiting interactions between lncRNAs and mRNA/miRNAs to lncRNA functional similarity (LFS) is an effective method to explore function of lncRNAs and predict novel lncRNA-disease associations. In this article, we pr...

2016
Xiangxiang Zheng Haibo Hu Shiting Li

The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in numerous diseases, and aberrant lncRNA PVT1 expression has been associated with the development of cancer. However, the underlying mechanism by which lncRNA PVT1 affects cell invasion in esophageal cancer has been not demonstrated. In the current study, the expression of lncRNA PVT...

2017
Fang Yin Yanan Wang Jinfang Xue Haoyu Kuang Liya Liao Xiaojun Zhou

More and more studies have suggested that long non-coding RNAs (LncRNAs) are involved in different physiological or physiopathologic processes including the development of cancer. Previous studies have suggested long noncoding RNA AB073614 (lncRNA AB073614) is involved in ovarian cancer and glioma, but its role in colorectal cancer (CRC) is still unclear. A study was thus performed to examine t...

2016
Jia Sun Yuting Ruan Ming Wang Rongping Chen Na Yu Lei Sun Tiemin Liu Hong Chen

Circulating long non-coding RNAs (lncRNAs) serve as valuable biomarkers in a number of human diseases. However, lncRNA biomarkers have yet to be identified in obesity. We aim to characterize circulating lncRNA expression in obese and non-obese human subjects. First, we assessed the genome-wide circulating lncRNA expression profiles in blood from 3 obese and 3 non-obese human subjects. We found ...

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