Ursolic acid (UA) is the major active component of the loquat leaf extract (LLE) and several previous studies have indicated that UA may have the ability to prevent skeletal muscle atrophy. Therefore, we conducted a randomized, double-blind, and placebo-controlled study to investigate the effects of the LLE on muscle strength, muscle mass, muscle function, and metabolic markers in healthy adult...

Two modifications of the HPLC-ED method with respect to extraction procedure used have been developed for psilocin, the active metabolite of psilocybin, in human plasma using either liquid-liquid extraction (LLE) or automated on-line solid-phase extraction (on-line SPE). Each type of the sample preparation required a different HPLC system followed by electrochemical detection at 650 to 675 mV. ...

PURPOSE This study investigated the etiology of late language emergence (LLE) in 24-month-old twins, considering possible twinning, zygosity, gender, and heritability effects for vocabulary and grammar phenotypes. METHOD A population-based sample of 473 twin pairs participated. Multilevel modeling estimated means and variances of vocabulary and grammar phenotypes, controlling for familiality....

PURPOSE The primary objectives of this study were to determine the prevalence of late language emergence (LLE) and to investigate the predictive status of maternal, family, and child variables. METHOD This is a prospective cohort study of 1,766 epidemiologically ascertained 24-month-old singleton children. The framework was an ecological model of child development encompassing a wide range of...

Locally Linear Embedding (LLE) is an elegant nonlinear dimensionality-reduction technique recently introduced by Roweis and Saul [2]. It fails when the data is divided into separate groups. We study a variant of LLE that can simultaneously group the data and calculate local embedding of each group. An estimate for the upper bound on the intrinsic dimension of the data set is obtained automatica...

This paper evaluates the performance of liquid-liquid extraction (LLE) and solid phase extraction (SPE) in separating and concentrating aqueous fullerene (nC(60)) from wastewater and compares UV-vis spectroscopy and mass spectrometry for the quantification of C(60). LLE was suitable for multiple wastewater matrices, while SPE required filtration or reclaimed wastewater and secondary effluent of...

For more features massive data sets efficiently reduction problems, to enhance the data uniformity of the near target instance, reduce the errors of represented neighbors, improve the effect of dimension reduction, proposed a dynamic K value method of massive data reduction based on improved LLE algorithm. Utilized the search algorithms based center point, searched an example neighborly, to ens...