BACKGROUND The strongest predictor of tumor relapse after liver transplantation for hepatocellular carcinoma (HCC) is vascular invasion, appreciated only on explant analysis. High serum level of vascular endothelial growth factor (VEGF) is associated with worse outcomes after resection or locoregional therapies but its role in liver transplantation remains undefined. OBJECTIVE We report the f...

P REVIOUS studies in liver transplant patients have demonstrated that liver allografts matched for HLA. especially HLA-DR, have lower survival rates, raising the concept that HLA plays a dualistic role in liver transplan-tation. HLA matching will reduce rejection but may augment other major histocompatibility complex (MHC) restricted cellular immune mechanisms of liver allograft injury. 1.2 The...

patients and methods tae was performed on 20 patients with liver hemangioma. the embolic agent used was polyvinyl alcohol (pva) particles (300-400 micron, jonson and johnson cordis, usa). all patients were followed up for 6 months. imaging was carried out and patients were also evaluated symptomatically through telephone interview by a physician. results twenty patients aged from 21 to 63 years...

OBJECTIVE To examine the phenotypic expression of CYP2E1 in liver transplant patients, as measured by the in vivo probe chlorzoxazone, and to evaluate CYP2E1 activity over time after transplantation. METHODS Thirty-three stable liver transplant patients were given 250 mg chlorzoxazone within 1 year after transplantation as part of a multiprobe CYP cocktail; urine and blood were collected for ...

The shortage of organs forces coordinators to seek new forms of generating organs for transplantation of the increasing numbers of patients on waiting lists. A recent technique called sequential transplant or domino liver transplant (DLT) allows the transplantation of a patient with chronic liver disease by implantation of a full-size liver derived from a patient with familial amyloidosis polyn...

Survival rates after liver transplantation have increased dramatically over the past 20 years. Cardiovascular disease is most common extra-hepatic cause of mortality in long-term post transplant. This intimately linked with both higher pre-existing metabolic syndrome these patients as well propensity to develop de novo post-transplant. unfavorable profile that contributes cardiovascular multifa...

patients with irreversible end-stage liver disease or acute hepatic failure in whom conventional medial therapy has been ineffective. Since the initiation of liver transplants in the 1960s, this procedure has been performed with increasing frequency and as a result, related medical and surgical complications have become more common (1). Although the incidence of liver-transplant-related complic...

The immunonutrients arginine and omega-3 fatty acids decrease adverse outcomes after solid organ transplant in humans and experimental animals. Kidney transplant recipients who received daily supplements with arginine (9 g) and canola oil (30 mL) had significantly lower frequencies of complications between 30 days to 3 years than transplant recipients who did not receive supplements. In another...

-The success of liver transplantation has created unexpected challenges for physicians and surgeons caring for patients with chronic liver disease or acute liver failure. Specifically, with all of these legitimate candidates for liver transplantation, how does one prioritize them given the unfortunate issue of limited donor availability? The answer to that problem has undergone several iteratio...

OBJECTIVES Recently, gamma-glutamyl transpeptidase has garnered increased attention as a diagnostic tool in the early identification of liver disease. However, its value in liver transplant is largely unknown, as the disease processes leading to abnormal gamma-glutamyl transpeptidase levels and the expected temporal trends in gamma-glutamyl transpeptidase levels during the period after liver tr...