Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet, against metabolic and cardiovascular diseases, can be attributed to the action of polyphenolic components of extra-virgin olive oil (EVOO). Here, we evaluated the protective effects of oleacein, one of the most abundant secoiridoids in EVOO, on the damages/metabolic alterations caused by high-fat diet ...

OBJECTIVE To evaluate the protective effects of ischemic preconditioning in a prospective randomized study involving a large population of unselected patients and to identify factors affecting the protective effects. SUMMARY BACKGROUND DATA Ischemic preconditioning is an effective protective strategy in several animal models. Protection has also been suggested in a small series of patients un...

Previous studies have demonstrated that mice disrupted with the cyclooxygenase-2 gene showed much more severe liver damage compared with wild-type mice after liver injury, and prostaglandins (PGs) such as PGE(1/2) and PGI(2) have decreased hepatic injury, but the mechanisms by which prostaglandins exhibit protective action on the liver have yet to be addressed. In the present study, we investig...

haemorraghic-shock, and 1(5%) with acute liver failure. Differences between non-survivours and survivours by (x2): hypofibrinogenemia (53%versus 13%; P 1⁄4 0.039), epistaxis (17% versus 0%; P 1⁄4 0.023), evident clinical infection (47%versus 13%; P 1⁄4 0.044), elevated LDH levels (63% versus 30%; P 1⁄4 0.039), hemophagocytosis (57% versus 17%; P 1⁄4 0.024). Risk factors associated to mortality:...

Purpose: To determine the in vivo and vitro hepatoprotective effects of Ficus carica.Methods: The methanol leaf extract carica L was further fractionated into n-hexane, ethyl acetate aqueous fractions. For study, male albino mice were divided twelve groups. Hepatotoxicity induced using carbon tetrachloride (CCl4). F. its fractions administered at doses 200 400 mg/kg. Silymarin used as standardh...

background: acantholimon gilliati turril(plumbaginaceae) is used in variety of diseases including hepatic ailments in the west region of iran. aim of the study: to investigate the hepatoprotective effect of methanoilc extract (me) of a. gilliati on formaldehyde (fa) induced liver injury in adult male mice.materials and methods: fifty six adult male mice were divided into 8 groups. in control gr...

background: several herbal remedies are used in traditional medicine for treatment of liver disorders, but their efficacy, safety, and dosage have not been investigated so far. objective: the present study was aimed to evaluate the liver protective effects of medicinal herbs extracts such as cynara scolymus leave (artichok), cichorium intybus roots (chichory), taraxacum officinale root (dandeli...

The aim of this study was to investigate the possible protective effect of Nigella sativa oil (NSO) and compared with the N-acetylcysteine (NAC), an antioxidant which is known to have liver protective effects, against thioacetamide (TAA)-induced liver injury. Accordingly, we aimed to investigate the toxicity of a hepatotoxic agent, thioacetamide, compared the NSO and NAC liver preventive effect...

Objective(s): Populus species have various pharmacological properties, including antioxidant activity. In this study, the effects of Populus tomentiglandulosa extract (PTE) on histopathology and antioxidant enzymes in the rat liver and kidney were examined.  Materials and Methods: Sprague-Dawley rats were assigned to three groups; (1) no...

Chronic exposure to coplanar polychlorinated biphenyls (PCBs), a potent inducer of toxic reactive oxygen species (ROS), in the environment and food can cause liver diseases. It remains unknown whether caffeic acid derivatives (CADs) exerted protective effect on PCB-induced hepatotoxicity. We sought to evaluate the activities of 3 CADs on PCB169-induced oxidative stress and DNA damage in the liv...