Neuroendocrine neoplasms (NENs) are a distinctive entity, and nearly 10% of patients already have liver metastases at presentation. The management of neuroendocrine liver metastases (NEN-LM) is complex with differing patterns of metastatic presentation. An aggressive approach should be used to resect the primary tumor, to remove regional lymph nodes, and to resect or treat appropriate distant m...

Pro\'iding the anatomic conditions are appropriate, removal of as much as 85-90% of the liver is a relatively safe technique for the treatment of benign or malignant prlmal) hepatic tumors and of isolated hepatic metastases. There have been apparent cures of malignant disease by this approach, but the paucity of concentrated experience at anyone center and the failure so far to pool data from d...

Meningiomas are usually slow growing neoplasms that follow a benign clinical course. However, atypical and anaplastic meningiomas can show more aggressive behaviour have the potential to metastasise. The most common sites for metastases lung, spine, soft tissue, liver bone. Bone exceedingly rare. We report case of 70-year-old man with previous history recurrent meningioma (WHO grade III) pathol...

PURPOSE mTOR and P70 S6 kinase (S6K) play a key role in regulating protein translation. The role of mTOR and S6K in hepatocellular carcinoma has not been investigated, but this pathway is of particular interest because an effective inhibitor, rapamycin, is available. This study was undertaken to determine the prevalence and clinicopathological correlates of mTOR pathway activation in hepatocell...

Granular cell tumors are rare soft tissue neoplasms, among which only 2% are malignant, arising from nervous tissue. Here we present a case of a large esophageal granular cell tumor with benign histopathological features which metastasized to the liver, but showing on positron emission tomography-computerized tomography standardized uptake value suggestive of a benign lesion.

Fine needle aspiration cytology has undergone increasing utilization in the evaluation of hepatic neoplasms. Experience with liver aspirates has demonstrated that problems in differential diagnosis require thorough understanding of criteria for distinguishing different tumor types. The present report describes the cytologic presentation of primary and metastatic hepatic tumors with emphasis on ...

To assess the effects of the combination of persistent hepadnavirus infection and chemical carcinogen exposure, aflatoxin B, (AFB) was administered p.o. for 60 days to congenitally duck hepatitis B virus (DHBV)-infected and virus-free Pékinducks, starting at 3 days of age, during a 28-month study. Hepatic neoplasia occurred only in AFB-dosed ducks. Hepatocellular carcinomas or biliary carcinom...

To assess the effects of the combination of persistent hepadnavirus infection and chemical carcinogen exposure, aflatoxin B1 (AFB) was administered p.o. for 60 days to congenitally duck hepatitis B virus (DHBV)-infected and virus-free Pekin ducks, starting at 3 days of age, during a 28-month study. Hepatic neoplasia occurred only in AFB-dosed ducks. Hepatocellular carcinomas or biliary carcinom...