Imaging procedures play a fundamental role in the therapeutic management of focal liver lesions. The goals of imaging are to detect and correctly characterize focal liver lesions. This review highlights the performances of newer, liver-specific, contrast media in the diagnosis of focal liver lesions, particularly Gd-EOB-DTPA (Primovist), the most frequently used liver specific contrast media. I...

Metastases are the most common malignant liver lesions and the most common indication for hepatic imaging. Specific characterization of liver metastases in patients with primary non-hepatic tumors is crucial to avoid unnecessary diagnostic work-up for incidental benign liver lesions. Magnetic resonance (MR) is rapidly emerging as the imaging modality of choice for detection and characterization...

Background: Iron chelators are an important part of management of patients with thalassemia. It is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. We aimed to compare the efficacy and safety of available oral iron chelator; Deferasirox (Exjade®) with Deferasirox (Osveral®) in reducing iron ove...

Focal, segmental, and diffuse liver pathologies have been described in the literature. This article describes a pattern in which liver pathology is confined to a lobe. This lobar pattern has not been described previously to our knowledge. Herein, we illustrate computed tomography (CT) and magnetic resonance imaging (MRI) findings of diffuse lobar involvement patterns in various ...

Abstract Background Accurate characterization of small nodules in a cirrhotic liver is challenging. We aimed to determine the additive value MRI-based radiomics analysis Liver Imaging Reporting and Data System version 2018 (LI-RADS v 2018) algorithm differentiating (≤ 3 cm) hepatocellular carcinomas (HCCs) from benign liver. Methods In this retrospective study, 150 cirrhosis patients with histo...

PURPOSE: Liver perfusion can be quantified from bolus-tracking MRI with an extracellular tracer and a dual-inlet onecompartment model [1]. The liver-specific contrast agent GdEOB-DTPA is taken up in the hepatocytes, and therefore has the potential to provide an additional and more direct measure of liver function [2,3]. The aim of this study is to develop and validate a tracer-kinetic model for...

PURPOSE To investigate the utility of dynamic contrast-enhanced MRI (DCE-MRI) with Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for detecting liver fibrosis induced by carbon tetrachloride (CCl4) in rats. METHODS This study was approved by the institutional animal care and use committee. Liver fibrosis in rats was induced by intraperitoneal injection of 1 mL/kg 50...

Magnetic resonance imaging (MRI) and (1)H magnetic resonance spectroscopy ((1)H-MRS) have been used in clinics for diagnosis of chronic liver diseases. This study was designed to investigate the relationship between MRI/MRS outcomes and the severity of liver damage. Of 50 patients examined, the MRI signal intensity in the globus pallidus as determined by pallidus index (PI) increased as the dis...

PURPOSE To investigate the value of perfusion-weighted MRI in the evaluation of the intranodular hemodynamic characteristics of dysplastic nodules (DNs) and hepatocellular carcinomas (HCCs) in an experimental rat model. MATERIALS AND METHODS A total of 40 rats with chemically-induced DNs and HCCs were investigated. Single-slice gadolinium-enhanced perfusion-weighted MRI was performed to evalu...

This retrospective study was to investigate whether adding diffusion-weighted imaging (DWI) to Gd-EOB-DTPA-enhanced MRI (EOB-MRI) improved the detection of liver metastasis in radiology resident and board-certified radiologist groups. It was approved by our institutional review board. We selected 18 patients with 35 liver metastases and 12 patients without liver tumors. Five board-certified rad...