نتایج جستجو برای: littermate
تعداد نتایج: 1477 فیلتر نتایج به سال:
Two hr after birth, newborn rats were given a subcutaneous injection of 0.01 mg estradiol benzoate dissolved in 0.05 ml sesame oil. Other siblings were given sesame oil alone. Autopsy was performed on days 1, 2 and 3 after birth. Gravimetric and histologic examinations of the adrenals from these animals and from normal littermate controls were made together with the determination of plasma cort...
To determine if phenotype and the carbohydrate type resulted in alterations brain composition obese of congenic LA/Ntul//-cp rat, groups (n= 8 rats/group) male littermate lean rats were fed standardized isocaloric diets containing 54% (w/w) cornstarch (ST diet) or sucrose (SUC from 1 until 10.5 ± 0.5 months age. The his strain develops early onset chronic hyperinsulinemia without NIDDM associat...
Evidence is emerging that neuronal nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine (DA) system are involved in mediating the reinforcing effects of alcohol. Midbrain DA neurons express high levels of α6 subunit-containing nAChRs that modulate DA transmission, implicating their involvement in reward-related behaviours. This study assessed the role of α6-containing nAChRs in...
Four trials were conducted to determine the influence of feeding 200 ppb Cr as chromium picolinate (CrPic) on DM digestibility, N balance, and carcass traits of growing-finishing pigs. A 15% CP corn-soybean meal diet was fed during the grower phase, and a 13% CP corn-soybean meal diet was fed during the finisher phase. In each of three trials, crossbred barrows (six littermate pairs) were used ...
Glycogen synthase kinase-3 (GSK3) is a constitutively active protein kinase in brain. Increasing evidence has shown that GSK3 acts as a modulator in the serotonin neurotransmission system, including direct interaction with serotonin 1B (5-HT1B) receptors in a highly selective manner and prominent modulating effect on 5-HT1B receptor activity. In this study, we utilized the serotonin neuron-sele...
Oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor (HIF) by a set of closely related prolyl hydroxylase domain enzymes (PHD1, 2 and 3) regulates a range of transcriptional responses to hypoxia. This raises important questions about the role of these oxygen-sensing enzymes in integrative physiology. We investigated the effect of both genetic deficiency and pharmacological inhibiti...
NADPH-cytochrome P450 oxidoreductase (POR) is the primary electron donor for cytochromes P450, dehydrocholesterol reductase, heme oxygenase, and squalene monooxygenase. Human patients with specific mutations in POR exhibit severe developmental malformations including disordered steroidogenesis, sexual ambiguities and various bone defects, similar to those seen in patients with Antley-Bixler syn...
Genomewide association studies have linked a polymorphism in the zinc transporter 8 (Znt8) gene to higher risk of developing type 2 diabetes. Znt8 is highly expressed in pancreatic β-cells where it is involved in the regulation of zinc transport into granules. However, Znt8 is also expressed in other tissues including α-cells, where its function is as yet unknown. Previous work demonstrated tha...
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