In the VALUE trial, new-onset diabetes arose in significantly fewer hypertensive patients on valsartan, an angiotensin receptor AT1 blocker (ARB), than on amlodipine, a metabolically neutral calcium-channel blocker, after a mean follow-up of 4.2 years. This finding confirms and extends the results of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) in whi...

A high performance liquid chromatographic method was developed, validated and applied for determination of lisinopril in pharmaceutical formulations. A LiChrospher RP-18 (10 μm, 250x 4 mm) column was used with a mobile phase consisting of acetonitrile: phosphate buffer (30: 70% v/v, pH 2.0), a quantitative evaluation was performed at 215 nm with flow rate of 1 mL/min, and column cooler temperat...

Hypochlorites efficently dehydrate hydroperoxyacetals to furnish the corresponding esters. The reaction, which can be accomplished with stoichometric Ca(OCl)(2) or with catalytic amounts of t-BuOCl, appears to involve formation and heterolytic fragmentation of secondary chloroperoxides, species not previously described in solution chemistry.

Janus green B (JG-B) dye is used for vital staining of mitochondria and its reduction and oxidation shows the electron transfer chain alteration. The defect in electron transfer chain of mitochondria by paraquat is linked to free radical formation. In this present study we compared the abilities of different angiotensin-converting enzyme inhibitors, captopril (a thiol ACEi), enalapril, and lisi...

Hypertension and hyperlipidemia are potent cardiovascular risk factors. Treatment can lower blood pressure and reduce events, but the optimal drug for initial hypertension treatment and the benefits of long-term cholesterol reduction on clinical outcomes in understudied hypertensive subpopulations were unknown. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALL...

Concerns exist that diuretic-induced changes in serum potassium may have adverse effects in hypertensive patients. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, a large practice-based clinical trial, made it possible to examine consequences of observed changes in potassium during care in conventional practice settings. Normokalemic participants randomized to c...

New plant growth regulators, named chloroisosulochrin, chloroisosulochrin dehydrate and pestheic acid, have been isolated from the culture filtrate of Pestalotiopsis theae grown on a Raulin-Thom medium. Their structures have been established by spectroscopic and chemical methods. The biological activities of these compounds have been examined using bioassay methods with lettuce and rice seedlings.

Pemphigoid diseases are a group of blistering autoimmune pathologies including pemphigus vulgaris (PV) and foliaceous, which affect mucocutaneous tissues. Non-steroidal anti-inflammatory drugs, penicillamine, angiotensin-converting enzyme inhibitors such as captopril enalapril associated with drug-induced pemphigoid. We present case lisinopril-associated PV has not been previously reported.