The lysosome is the final destination for degradation of endocytic cargo, plasma membrane constituents, and intracellular components sequestered by macroautophagy. Fusion of endosomes and autophagosomes with the lysosome depends on the GTPase Rab7 and the homotypic fusion and protein sorting (HOPS) complex, but adaptor proteins that link endocytic and autophagy pathways with lysosomes are poorl...

Working memory performance is influenced by dopamine activation of D1 family dopamine receptors in the prefrontal cortex; working memory performance is maximal at moderate stimulation of D1 family receptors and is reduced by either higher or lower levels of D1 stimulation. The neuronal mechanisms that underlie this complex relationship are not yet understood. Previous work from this laboratory ...

BACKGROUND The clinical characteristics of elderly patients with AML differ from those of younger patients, resulting in poorer survival and treatment outcomes. We analyzed retrospectively the clinical data of AML patients 65 years old and above to describe patients' characteristics and treatment patterns, and to define meaningful prognostic factors of survival in the Korean population. METHO...

In his Incomplete Nature, Deacon extends a thermodynamic concept of energy to yield a description of complex processes in which absence plays a critical role in their emergence and evolution. Starting from a quantum-mechanical picture of energy as an energy-matter duality, the critical role of potential as well as actual properties of processes is also described in the new extension of logic to...

Within Gastropoda, limpets (Patellogastropoda) are considered the most basal branching taxon and its representatives are thus crucial for research into evolutionary questions. Here, we describe the development of the neuromuscular system in Lottia cf. kogamogai. In trochophore larvae, first serotonin-like immunoreactivity (lir) appears in the apical organ and in the prototroch nerve ring. The a...

We recently reported that degenerating motor neurons of superoxide dismutase mutant 1 (SOD1) rodents exhibit immunoreactivity to P2X4 antibodies. Neurons with strong P2X4-like immunoreactivity (P2X4-LIR) do not show an apoptotic phenotype and are often associated with microglial cells that display neuronophagic activity. Western blot analysis showed that P2X4 antibodies recognize not only the P...

The purpose of this study was to demonstrate two cases of vertical diplopia after cataract surgery and to discuss the mechanism and types of strabismus caused by the local anesthesia with retrobulbar injection. Two cases of vertical diplopia after cataract surgeries were reported. They were operated by the same surgeon and both happened to the left eye and both presented with marked left hypotr...

We present the spectral energy distribution (SED) between 10 and 200 μm obtained for the prototype Narrow-Line X-Ray Galaxy NGC 7582 with ISOPHOT, the photometer on board the Infrared Space Observatory. The emission is spatially extended and we separated for the first time the nuclear and extranuclear infrared SEDs. The nuclear luminosity (LIR ∼ 4.5×10 10 L⊙) is dominated by cold (T ∼ 32 K) dus...

Replication, DNA organization, and mismatch repair (MMR) can influence recombination. We examined the effects of altered replication due to a mutation in the polymerase delta gene, long inverted repeats (LIRs) in motifs similar to those in higher eukaryotes, and MMR on intrachromosomal recombination between highly diverged (28%) truncated genes in Saccharomyces cerevisiae. A combination of alte...

Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from t...